1-Methyl-1,3,8-triazaspiro[4.5]decan-2-one | 1368527-91-6

• 英文名称: 1-Methyl-1,3,8-triazaspiro[4.5]decan-2-one
• CAS: 1368527-91-6
• 化学式: C₈H₁₅N₃O
• mdl: MFCD21875104
• 分子量: 169.22
• InChiKey: GIHYAWRCQRJWNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• NOVEL PYRIDAZINES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210024492A1

  公开（公告）日：2021-01-28

  The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.

  本发明涉及新型吡啶嗪，其制备方法，包含它们的药物组合物以及它们在治疗中的应用，特别是在由自体循环素介导的疾病和疾病预防和/或治疗中的应用。
• [EN] 1-(6-(METHOXY)PYRIDAZIN-3-YL)CYCLOPROPANE-1-CARBOXAMIDE DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES<br/>[FR] DÉRIVÉS DE 1-(6-(MÉTHOXY)PYRIDAZIN-3-YL)CYCLOPROPANE-1-CARBOXAMIDE SERVANT DE MODULATEURS DE L'AUTOTAXINE (ATX) POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES DES VOIES RESPIRATOIRES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2021013832A1

  公开（公告）日：2021-01-28

  The present invention relates to 1-(6-(methoxy)pyridazin-3-yl) cyclopropane-1-carboxamide derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IPF) or systemic sclerosis (SSc). The present description discloses exemplary compounds (e.g. pages 50 to 65; examples 1.1 to 1.31) as well as relevant biological data thereof (e.g. pages 14 to 21, tables 1 to 9). An exemplary compound is e.g. N-(4-(7-acetyl-2,7- diazaspiro[3.5]nonan-2-yl)benzyl)-1-(6-((6-(trifluoromethyl)pyridin-3- yl)methoxy)pyridazin-3-yl)cyclopropane-1-carboxamide (example 1.1).