Zinc(2-acetylpyridine-N-oxide-4N-methylthiosemicarbazone)(II) bromide | 267895-83-0

• 英文名称: Zinc(2-acetylpyridine-N-oxide-4N-methylthiosemicarbazone)(II) bromide
• 英文别名: Zn(H4MLO)Br2
• CAS: 267895-83-0
• 化学式: C₉H₁₂Br₂N₄OSZn
• 分子量: 449.484
• InChiKey: YCMULNCADOHBTL-DLEJXUKQSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  N-oxo-2-acetylpyridine (4)N-methylhtiosemicarbazone 、 zinc dibromide 以 乙醇 为溶剂， 以45%的产率得到Zinc(2-acetylpyridine-N-oxide-4N-methylthiosemicarbazone)(II) bromide
  参考文献：
  名称：

  Complexes of Group 12 Metal Dihalides with 2‐Acetylpyridine‐ N ‐oxide ⁴ N ‐methylthiosemicarbazone (H4MLO). The Crystal Structures and Organization of [Zn(H4MLO)X ₂ ] (X = Br, I)

  摘要：

  Reaction of group 12 metal dihalides with 2-acetylpyridine-N-oxide N-4-methylthiosemicarbazone (H4MLO) in ethanol afforded compounds [M(H4MLO)X-2] (M = Zn-II Cd-II, Hg-II; X = Cl, Br, I), the structures of which were characterized by elemental analysis and by IR and H-1 and C-13 MMR spectroscopy. In addition, the complexes of ZnBr2 and ZnI2 were analysed structurally by X-ray diffractometry In [Zn(H4MLO)Br-2] the ligand is O,N,S-tridentate and the metal is pentacoordinated. while in [Zn(H4MLO)I-2] the thiosemicarbazone is S,O-bis-monodentate and the Zn cation has a distorted tetrahedral coordination polyhedron. In assays of antifungal activity against Aspergillus niger and Paecilomyces variotii, only the mercury compounds showed any activity, and only [Hg(H4MLO)Cl-2] and [Hg(H4MLO)I-2] were competitive with nystatin against A. niger.

  DOI：

  10.1002/(sici)1521-3749(200004)626:4<878::aid-zaac878>3.0.co;2-#