| 1421712-53-9

• CAS: 1421712-53-9
• 化学式: BF₄*C₄₆H₄₇NO₂P₂Rh
• 分子量: 897.542
• InChiKey: YMTLBOPTLNZJJO-ONEVTFJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 、 (11bS)-N-(3-(diphenylphosphino)propyl)-N-isopropyl-{dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-2-yl}-4-amine 以 二氯甲烷 为溶剂， 反应 0.33h， 生成
  参考文献：
  名称：

  Fine tuning of the structure of phosphine–phosphoramidites: application for rhodium-catalyzed asymmetric hydrogenations

  摘要：

  Diastereomers of (4-(diphenylphosphino)pentan-2-yl)-N-isopropyl-{dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-2-yl}-4-amine, (S)-(2S,4S)-1, and (S)-(2R,4R)-3; the octahydro derivative 4 of (S)-(2S,4S)-1, and derivative 2 of (S)-(2S,4S)-1 containing a 1,3-propanediyl backbone, have been synthesized and used for rhodium-catalyzed asymmetric hydrogenations of prochiral olefins in order to study the role of the stereogenic elements in the backbone and in the terminal moiety. The central chirality in the bridge has been found to determine the configuration of the product with a cooperative effect from the terminal groups. Excellent ee's (up to 99.9%) were obtained in the hydrogenation of methyl (Z)-alpha-acetamidocinnamate using a rhodium complex with the matched arrangement (S)-(2S,4S)-1. The hydrogenation is accomplished in a highly enantioselective manner by using green solvents such as propylene carbonate. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.11.013