[Pd(2ppy*)(NH₃)Cl] | 76857-96-0

• 英文名称: [Pd(2ppy*)(NH₃)Cl]
• 英文别名: b-ammine-a-chloro-dc-[2-(2'-pyridyl)phenyl-N',C]palladium
• CAS: 76857-96-0
• 化学式: C₁₁H₁₁ClN₂Pd
• 分子量: 313.095
• InChiKey: LIXGRZYFJCMKKT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pd(2ppy*)(NH₃)Cl] 以 solid 为溶剂， 生成 氨 、 di-μ-chlorobis{(2-phenylpyridine)palladium(II)}
  参考文献：
  名称：

  摘要：

  The complex [Pd(2-Phpy)(mu -Cl)](2) reacts with pyridines (L=pyridine, alpha -picoline and gamma -picoline), amines (L=isopropylamine, tert-butylamine) and ammonia to form the corresponding ortho-palladated derivatives [Pd(2-Phpy)ClL]. The compounds have been characterized by C, H and N analyses and spectroscopic methods (IR and H-1 and C-13 NMR). TG, DTG and DSC studies of the complexes were carried out in dynamic nitrogen atmosphere, From DSC analyses the heats of decomposition were calculated. The kinetics of the first step of thermal decomposition were evaluated from TG data by isothermal methods for L=pyridine and isopropylamine. The activation energies obtained are in the range 90-100 kJ mol(-1). The best fitting for data was observed for R2 and A1.5 kinetic models.

  DOI：

  10.1023/a:1013118929427
• 作为产物：
  描述：

  氨 、 bis[(2-phenylpyridinato-C(2'),N(1))(μ-chlorido)palladium(II)] 以 甲醇 、 二氯甲烷 为溶剂， 以73%的产率得到[Pd(2ppy*)(NH₃)Cl]
  参考文献：
  名称：

  In vitro and in vivo studies of neutral cyclometallated complexes against murine leukæmias

  摘要：

  从氮配体（1-苯基吡唑，2-苯基吡啶和1-(2'-吡啶基)吲哚）衍生的环金属µ-卤代二聚体与一价氮和磷配体处理，形成了一系列中性单核钯(II)和铂(II)配合物。对这些配合物对小鼠淋巴细胞白血病细胞系L1210的初步筛选表明，这些配合物在相对宽的浓度范围内表现出生长抑制活性。导致增加活性的两个因素是金属中心周围的立体位阻，这是由于受阻配体（如2,6-二甲基吡啶）或磷配体的存在。钯和铂配合物之间几乎没有明显的相关性。选择了四种配合物进行进一步的体内研究，尽管在低于毒性水平的剂量下，没有一种钯配合物显示出对P388白血病的活性超过边缘水平，但一种金配合物，其金属中心受阻，确实显示出对这一模型的显著抗肿瘤活性。关键词：环金属化，钯，铂，细胞毒性，抗癌。

  DOI：

  10.1139/v05-109

文献信息

• Structural and 1H, 13C, 15N NMR spectroscopic studies of Pd(II) chloride organometallics with 2-phenylpyridine and ammonia, pyridine or its methyl derivatives
  作者：Daria Niedzielska、Tomasz Pawlak、Andrzej Wojtczak、Leszek Pazderski、Edward Szlyk

  DOI：10.1016/j.poly.2015.02.028

  日期：2015.5

  Pd(II) chloride organometallics with 2-phenylpyridine and pyridines of general formula [Pd(2ppy*)LCl] (2ppy* = C(2')-deprotonated form of 2-phenylpyridine (2ppy), acting as N(1),C(2')-chelating ligand; L = NH3, pyridine, 2-, 3-, 4-methylpyridine, 2,3-, 2,4-, 2,6-, 3,5-dimethylpyridine, 2,4,6-trimethylpyridine) were studied by H-1, C-13 and N-15 NMR. H-1, C-13 and N-15 NMR coordination shifts (i.e. differences of chemical shifts for the same atom in the complex and ligand molecules) were discussed in relation to the molecular structures. Single crystal X-ray structure of trans(N,N)-[Pd(2ppy*)(2,4,6col)Cl] was solved. The analysis of 15N NMR coordination shifts for the whole series of the studied organometallics exhibited that all of them had an analogous trans(N,N) geometry. (C) 2015 Elsevier Ltd. All rights reserved.