Cu₂(-μCl)(κ¹S,κ¹S-dtucH)(PPh₃)₄ | 1642796-88-0

• 英文名称: Cu₂(-μCl)(κ¹S,κ¹S-dtucH)(PPh₃)₄
• 英文别名: Cu₂(-μCl)(κ¹S,κ¹S-dithiouracil)(PPh₃)₄
• CAS: 1642796-88-0
• 化学式: C₇₆H₆₃ClCu₂N₂P₄S₂
• 分子量: 1354.92
• InChiKey: PTKGXMQEJSQQPY-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  二硫代脲 、 [CuCl(PPh₃)]₄ 以 甲醇 、 乙腈 为溶剂， 反应 2.0h， 以34%的产率得到Cu₂(-μCl)(κ¹S,κ¹S-dtucH)(PPh₃)₄
  参考文献：
  名称：

  Structural diversity in dinuclear copper(I) halide complexes of 2,4-dithiouracil: Synthesis, crystal structures, induction of DNA damage and oxidative stress mediated by ROS

  摘要：

  2,4-Dithiouracil (dtucH(2)) reacts with [CuX(PPh3)](4) (X = Cl, Br, I) to give dinuclear complexes with different bridging motifs, namely doubly bridged [Cu-2(mu-Cl)(mu-S,S-dtucH)(PPh3)(4)] (1), single bridged [Cu2Br2 (mu-S,S-dtucH(2))(PPh3)(4)] (2) and triply bridged [Cu-2(mu-I)(2)(mu-S,S-dtucH(2))(PPh3)(2)] (3). In the structure of 1 the two copper(I) centers are joined by one bridging chlorine atom as well as a 2,4-dithiouracil anion acting as an 5,S-donor, while compound 3 contains two bridging iodine atoms besides the neutral bridging 2,4-dithiouracil ligand. The structure of 2 consists of two CuEr(PPh3)(2) sub-units joined by the S-atoms of a neutral dtucH(2). The biological properties of the new complexes were evaluated in relevance to their binding with calf-thymus double stranded DNA (dsCTDNA) in vitro monitored by mobility shift experiments in agarose gel electrophoresis, and their ability to induce oxidative stress in bacteria Escherichia coll. The experiments showed that these complexes are able to interact with dsCTDNA and to cause DNA damage, and are also able to induce oxidative stress in bacteria. Because of the relevance of these properties, these complexes are regarded as a very promising starting point for biological studies in living systems. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.12.012

文献信息

• Coordination variability of Cu^Iin multidonor heterocyclic thioamides: synthesis, crystal structures, luminescent properties and ESI-mass studies of complexes
  作者：Tarlok S. Lobana、Amanpreet K. Sandhu、Razia Sultana、Alfonso Castineiras、Ray J. Butcher、Jerry P. Jasinski

  DOI：10.1039/c4ra02748e

  日期：——

  (tucH2) with copper(I) chloride and PPh3 yielded a tetrahedral complex, [CuCl(κ1S-tucH2)(PPh3)2] (3). Purine-6-thione (purSH2) coordinated to CuI in two different modes yielding mono- and di-nuclear complexes, [Cu(κ1N,κ1S-purS)(PPh3)2]·CH3OH (2a) and [Cu2(κ1N,μ-S-purS)2(PPh3)2] (2b). The existence of bond isomers (6a and 6b), synthesis of novel dinuclear (4 and 5) and rare trinuclear (7) complexes with unusual

  描述了铜（I）与很少研究的杂环硫酰胺，特别是2,4,6-三巯基三嗪，嘌呤-6-硫酮，2,4-二硫尿嘧啶，2-硫尿嘧啶和嘧啶-2-硫酮的化学反应。2,4,6- trimercaptotriazine的（屯门大会堂的相互作用3）与[铜（CH 3 COO）（PPH 3）2 ]导致的一对键的异构体：[铜（κ 1的N-屯门大会堂2）（PPH 3）2 ]（图6a），[Cu（上κ 1 N，κ 1 S-屯门大会堂2）（PPH 3）2 ]（图6b）; 与铜（我），溴化和PPH 3，它形成的三核配合物[铜3溴2（κ 1 N，κ 1 S，μ-S-屯门大会堂2）（PPH 3）6 ]（7用阴离子屯门大会堂）2 - 。2,4-二硫代与铜（我）卤化物（氯化亚铜，溴化亚铜）和PPH 3得到双核配合物：[铜2（μ-Cl）的（κ 1 S，κ 1 S-dtucH）（PPH 3）4 ]（4）和[铜2（μ-溴）（κ 1 S，κ 1