N-(4-hydroxybutyl)-N-methylsulfonylmethanesulfonamide | 14548-81-3

• 英文名称: N-(4-hydroxybutyl)-N-methylsulfonylmethanesulfonamide
• CAS: 14548-81-3
• 化学式: C₆H₁₅NO₅S₂
• 分子量: 245.321
• InChiKey: IJBQRNBHCYYQQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR RÉDUIRE AU SILENCE L'APOLIPOPROTÉINE B
  申请人：PROTIVA BIOTHERAPEUTICS INC

  公开号：WO2011141703A1

  公开（公告）日：2011-11-17

  The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.