4-Chlor-1-<2.3.4-trimethoxy-phenyl>-butan-1-on | 92019-50-6

• 英文名称: 4-Chlor-1-<2.3.4-trimethoxy-phenyl>-butan-1-on
• 英文别名: 4-Chloro-1-(2,3,4-trimethoxyphenyl)butan-1-one
• CAS: 92019-50-6
• 化学式: C₁₃H₁₇ClO₄
• 分子量: 272.729
• InChiKey: QSPQGFYONAQPHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Sigma-1 receptor ligand with acetylcholinesterase
  申请人：Papadopoulos Vassilios

  公开号：US20060247248A1

  公开（公告）日：2006-11-02

  A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against β-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-1 receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant.

  本研究公开了一种通过抑制乙酰胆碱酯酶和结合 sigma-1 受体来预防或治疗神经退行性疾病的新型化合物和方法。二甲基氨基甲酸 2,3-双-二甲基氨基甲酰氧基-6-[4-(4-乙基-哌嗪基)-丁酰基]-苯基酯及其衍生物在抑制乙酰胆碱酯酶、改善胆碱能传导、结合σ-1 受体以及释放一种既是σ-1 受体配体又是抗氧化剂的活性代谢物方面，代表了一种针对 β 淀粉样肽诱导的神经毒性的新型治疗策略。
• ANTIDOTES TO EXOGENOUS NEUROTOXIC AGENTS
  申请人：Papadopoulos Vassilios

  公开号：US20090176802A1

  公开（公告）日：2009-07-09

  A novel method for treating a mammal exposed to an exogenous neurotoxic agent is disclosed.