N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-4-(2,5-dimethyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide | 1052671-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-4-(2,5-dimethyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide
• 英文别名: 4-(2,5-Dimethyl-4,5,6,7-tetrahydro-1H-indol-1-YL)-N-[3-(2,6-dimethylpiperidin-1-YL)propyl]benzamide；N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-4-(2,5-dimethyl-4,5,6,7-tetrahydroindol-1-yl)benzamide
• CAS: 1052671-61-0
• 化学式: C₂₇H₃₉N₃O
• mdl: MFCD14907354
• 分子量: 421.626
• InChiKey: HULANHNBNWIAED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：Page Patrick

  公开号：US20100120749A1

  公开（公告）日：2010-05-13

  The present invention is related to tetrahydroindole derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的四氢吲哚衍生物，其药物组成物，其制备方法以及它们用于治疗和/或预防与尼克酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• Tetrahydroindole derivatives as NADPH Oxidase inhibitors
  申请人：GenKyo Tex

  公开号：EP2000176A1

  公开（公告）日：2008-12-10

  The present invention is related to tetrahydroindole derivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adcninc dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的四氢吲哚衍生物、其药物组合物、其制备方法及其用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH 氧化酶）有关的疾病或病症。
• COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY
  申请人：Codony-Soler Xavier

  公开号：US20100120747A1

  公开（公告）日：2010-05-13

  The present invention relates to an active substance combination comprising at least one compound with 5-HT6 receptor affinity, and at least one cholinesterase inhibitor, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
• US8288432B2
  申请人：——

  公开号：US8288432B2

  公开（公告）日：2012-10-16
• [EN] TETRAHYDROINDOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS<br/>[FR] DÉRIVÉS DE TÉTRAHYDROÏNDOLE EN TANT QU'INHIBITEURS D'OXYDASE DE NADPH
  申请人：GENKYO TEX

  公开号：WO2008116926A1

  公开（公告）日：2008-10-02

  [EN] The present invention is related to tetrahydroindolederivatives of Formula (I), pharmaceutical composition thereof, methods of preparation thereofand to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphateoxidase (NADPH Oxidase).
  [FR] La présente invention concerne des dérivés de tétrahydroïndole d'une formule (I), une composition pharmaceutique de ceux-ci, des procédés de préparation de ceux-ci et leur utilisation pour le traitement et/ou la prophylaxie de troubles ou de conditions liées à une phosphateoxydase de dinucléotide d'adénine nicotinamide (oxydase NADPH).