2-[4-((R)-2-methoxy-1-methyl-ethoxy)-3-methyl-phenyl]-5-[1,2,3]triazol-2-ylmethyl-[1,3,4]oxadiazole | 864178-31-4

• 英文名称: 2-[4-((R)-2-methoxy-1-methyl-ethoxy)-3-methyl-phenyl]-5-[1,2,3]triazol-2-ylmethyl-[1,3,4]oxadiazole
• 英文别名: 2-[4-[(2R)-1-methoxypropan-2-yl]oxy-3-methylphenyl]-5-(triazol-2-ylmethyl)-1,3,4-oxadiazole
• CAS: 864178-31-4
• 化学式: C₁₆H₁₉N₅O₃
• 分子量: 329.359
• InChiKey: BVQIOHQYFWWXBR-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS<br/>[FR] DERIVES DE TRIAZOLE SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DE L'OXYTOCINE
  申请人：PFIZER LTD

  公开号：WO2005082866A2

  公开（公告）日：2005-09-09

  The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).