[(η6-p-cymene)RuCl(C14H9CHNNHC(S)NH(Me))]Cl | 1228181-96-1

• 英文名称: [(η6-p-cymene)RuCl(C14H9CHNNHC(S)NH(Me))]Cl
• CAS: 1228181-96-1
• 化学式: C₂₇H₂₉ClN₃RuS*Cl
• 分子量: 599.589
• InChiKey: KTOBFESMVAIBIV-QDGKMWDNSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 二氯甲烷 、 9-anthraldehyde N(4)-methylthiosemicarbazone 以 二氯甲烷 为溶剂， 生成 [(η6-p-cymene)RuCl(C14H9CHNNHC(S)NH(Me))]Cl
  参考文献：
  名称：

  Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η6-p-cymene)Ru(NS)Cl]+ (NS=9-anthraldehyde thiosemicarbazones)

  摘要：

  A series of half-sandwich arene ruthenium complexes containing bidentate thiosemicarbazone ligands have been synthesized and their biological activity investigated. The compounds have the general formula [(6-p-cymene)Ru(R-ATSC)Cl]X (ATSC=9-anthraldehyde thiosemicarbazone and R=H, CH3 and C6H5). The crystal structure of [(6-p-cymene) Ru(MeATSC)Cl]Cl have been determined and represents the first structurally characterized arene-ruthenium half-sandwich complex with a thiosemicarbazone ligand. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines. (c) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2009.08.034