3-butyl-2-ferrocenyl-2,3-dihydroquinazolin-4(1H)-one | 1414933-30-4

• 英文名称: 3-butyl-2-ferrocenyl-2,3-dihydroquinazolin-4(1H)-one
• CAS: 1414933-30-4
• 化学式: C₂₂H₂₄FeN₂O
• 分子量: 388.292
• InChiKey: FSIUTRILYLHGKE-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  靛红酸酐 、 ferrocenecarboxaldehyde 、 正丁胺 在 sodium dodecyl-sulfate 、 酒石酸 作用下， 以 乙醇 、 水 为溶剂， 反应 0.05h， 以81%的产率得到3-butyl-2-ferrocenyl-2,3-dihydroquinazolin-4(1H)-one
  参考文献：
  名称：

  A Greener Protocol for Accessing 2,3-Dihydro/spiroquinazolin-4(1H)-ones: Natural Acid-SDS Catalyzed Three-Component Reaction

  摘要：

  A novel green and energy-efficient synthesis of 2,3-dihydro/spiroquinazolin-4(1H)-ones via three-component cyclo-condensation reaction involving isatoic anhydride, amines and aldehydes/ketones utilizing recyclable tartaric acid-SDS catalyst system has been achieved. With simple requirements of mechanical stirring or mechanochemical activation at room temperature and one of the shortest reported times as of yet, it is a significant improvement on previously described methods for the synthesis of such compounds. Moreover the catalyst system can also be efficiently applied in large-scale reactions which indicates the potential for applications in industry.

  DOI：

  10.1055/s-0032-1317014