N-(ferrocenylmethyl)-N’-(benzyl)ethane-1,2-diamine | 1593270-41-7

• 英文名称: N-(ferrocenylmethyl)-N’-(benzyl)ethane-1,2-diamine
• CAS: 1593270-41-7
• 化学式: C₂₀H₂₄FeN₂
• 分子量: 348.271
• InChiKey: PQIHVBIEBDUMJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  N-(ferrocenylmethyl)-N’-(benzyl)ethane-1,2-diamine 在 盐酸 作用下， 以 水 为溶剂， 以1.212 g的产率得到N-(ferrocenylmethyl)-N’-(benzyl)ethane-1,2-diamine dihydrochloride
  参考文献：
  名称：

  Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi

  摘要：

  Trypanosoma brucei and Trypanosoma cruzi are the etiologic agents of sleeping sickness and Chagas disease, respectively, two of the 17 preventable tropical infectious diseases (NTD) which have been neglected by governments and organizations working in the health sector, as well as pharmaceutical industries. High toxicity and resistance are problems of the conventional drugs employed against trypanosomiasis, hence the need for the development of new drugs with trypanocidal activity. In this work we have evaluated the trypanocidal activity of a series of N1, N2-dibenzylethane-1,2-diamine hydrochlorides (benzyl diamines) and N1-benzyl, N2-methyferrocenylethane-1,2-diamine hydrochlorides (ferrocenyl diamines) against T. brucei and T. cruzi parasite strains. We show that incorporation of the ferrocenyl group into the benzyl diamines increases the trypanocidal activity. The molecules exhibit potential trypanocidal activity in vitro against all parasite strains. Cytotoxicity assay was also carried out to evaluate the toxicity in HepG2 cells. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.046
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 1.5h， 生成 N-(ferrocenylmethyl)-N’-(benzyl)ethane-1,2-diamine
  参考文献：
  名称：

  Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi

  摘要：

  Trypanosoma brucei and Trypanosoma cruzi are the etiologic agents of sleeping sickness and Chagas disease, respectively, two of the 17 preventable tropical infectious diseases (NTD) which have been neglected by governments and organizations working in the health sector, as well as pharmaceutical industries. High toxicity and resistance are problems of the conventional drugs employed against trypanosomiasis, hence the need for the development of new drugs with trypanocidal activity. In this work we have evaluated the trypanocidal activity of a series of N1, N2-dibenzylethane-1,2-diamine hydrochlorides (benzyl diamines) and N1-benzyl, N2-methyferrocenylethane-1,2-diamine hydrochlorides (ferrocenyl diamines) against T. brucei and T. cruzi parasite strains. We show that incorporation of the ferrocenyl group into the benzyl diamines increases the trypanocidal activity. The molecules exhibit potential trypanocidal activity in vitro against all parasite strains. Cytotoxicity assay was also carried out to evaluate the toxicity in HepG2 cells. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.046