N-(5-bromopyrimidin-2-yl)pyridinium aminide | 1011794-15-2

• 英文名称: N-(5-bromopyrimidin-2-yl)pyridinium aminide
• CAS: 1011794-15-2
• 化学式: C₉H₇BrN₄
• 分子量: 251.085
• InChiKey: ZXIACPDZRZNICN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  N-(5-bromopyrimidin-2-yl)pyridinium aminide 、 4-甲氧基苯硼酸 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 5.0h， 生成 N-[5-(4-methoxyphenyl)pyrimidin-2-yl]pyridinium aminide
  参考文献：
  名称：

  Suzuki reaction on pyridinium N-haloheteroarylaminides: regioselective synthesis of 3,5-disubstituted 2-aminopyrazines

  摘要：

  An extensive study of Suzuki-Miyaura cross-coupling processes on N-pyridinium bromoazinyl aminides has been performed. Mono- and disubstitution on 5- and 3,5-bromo derivatives produced the corresponding aryl derivatives. In the disubstituted compounds regioselective substitution at the 3-position occurred, vicinal to the aminide nitrogen, and this was more evident in pyrazine derivatives. The commonly used strategy involving N-alkylation and reduction of the N-N bond gave rise to a series of 2-alkylamino-3,5-disubstituted-pyrazines. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.11.057
• 作为产物：
  描述：

  1-氨基吡啶碘 、 5-溴-2-氯嘧啶 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 14.0h， 以76%的产率得到N-(5-bromopyrimidin-2-yl)pyridinium aminide
  参考文献：
  名称：

  New approaches to the synthesis of pyridinium N-heteroarylaminides

  摘要：

  Different substituted pyridinium N-heteroarylaminides have been prepared in one step from N-aminopyridinium iodide and the Corresponding heteroaryl halide by two alternative routes. The use of Pd catalysis allowed the easy preparation of products from the less reactive haloheterocycles. The use of water as a solvent in conjunction with microwave heating dramatically diminishes the reaction time without having an adverse effect on reaction yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.024