R(-)-4-(3-fluoro-4-methoxyphenyl)-4-oxo-2-(N-trifluoroacetyl)aminobutanoic Acid | 221384-98-1

• 英文名称: R(-)-4-(3-fluoro-4-methoxyphenyl)-4-oxo-2-(N-trifluoroacetyl)aminobutanoic Acid
• 英文别名: (2R)-4-(3-fluoro-4-methoxyphenyl)-4-oxo-2-[(2,2,2-trifluoroacetyl)amino]butanoic acid
• CAS: 221384-98-1
• 化学式: C₁₃H₁₁F₄NO₅
• 分子量: 337.228
• InChiKey: XBIAKZYGVXKYHN-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• 2-AMINOTETRALINES AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES
  申请人：——

  公开号：US20020123652A1

  公开（公告）日：2002-09-05

  2-Aminotetralines, a process for their preparation, and pharmaceutical compositions. for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.

  2-氨基四氢噻唑啉，其制备方法和药物组合物，用于预防和治疗炎症病理（尤其是脓毒症）和/或自身免疫病理，其中已确定炎症细胞因子的病因作用。
• 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：US20030158266A1

  公开（公告）日：2003-08-21

  2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.

  2-氨基四氢萘胺、其制备方法和药物组合物，用于预防和治疗炎症性病变（尤其是脓毒性休克）和/或自身免疫性病变，在这些病变中，炎性细胞因子的致病作用已经得到确认。
• 2-Amino-6-methyl-7-acetyl-tetraline and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1017667B1

  公开（公告）日：2003-11-19
• US6207709B1
  申请人：——

  公开号：US6207709B1

  公开（公告）日：2001-03-27
• US6849663B2
  申请人：——

  公开号：US6849663B2

  公开（公告）日：2005-02-01