[IrIII(oep)Cl(CO)] | 109432-38-4

• 英文名称: [IrIII(oep)Cl(CO)]
• CAS: 109432-38-4
• 化学式: C₃₇H₄₄ClIrN₄O
• 分子量: 788.456
• InChiKey: PCBSJTBBQVXCAQ-SBYLDBAISA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [IrIII(oep)Cl(CO)] 、 以 二氯甲烷 为溶剂， 反应 12.0h， 以85%的产率得到
  参考文献：
  名称：

  [EN] IRIDIUM (III) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND THEIR USE THEREOF IN CANCER TREATMENT
  [FR] COMPLEXES D'IRIDIUM (III) CONTENANT UN LIGAND CARBÈNE N-HÉTÉROCYCLIQUE, SYNTHÈSE ET UTILISATION ASSOCIÉE DANS LE TRAITEMENT DU CANCER

  摘要：

  Provided herein are Ir (III) complexes comprising N-heterocyclic carbene ligand, method of synthesis of the Ir (III) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Ir (III) complexes under both dark and light conditions. Also provided is a method of detecting the Ir (III) complex in a biological system. Also provided is a method of making the Ir (III) complex The Ir (III) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.

  公开号：

  WO2020024969A1