4-Isobutyl-2-methyl-1H-imidazole | 86921-33-7

• 英文名称: 4-Isobutyl-2-methyl-1H-imidazole
• 英文别名: 2-methyl-5-(2-methylpropyl)-1H-imidazole
• CAS: 86921-33-7
• 化学式: C₈H₁₄N₂
• mdl: MFCD24394103
• 分子量: 138.213
• InChiKey: RCGMLWDMQYVICI-UHFFFAOYSA-N

物化性质

• 沸点：
  288.5±9.0 °C(Predicted)
• 密度：
  0.963±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-Isobutyl-2-methyl-imidazol-1-ol 在 titanium(III) chloride 作用下， 以 甲醇 为溶剂， 以87%的产率得到4-Isobutyl-2-methyl-1H-imidazole
  参考文献：
  名称：

  Ti（III）介导的N-羟基咪唑还原为1-protio-2,4（5）-二取代衍生物

  摘要：

  N-羟基咪唑在MeOH / H 2 O中将TiCl 3转化为N-protio衍生物，它们是手性氨基酸的有用前体。

  DOI：

  10.1016/s0040-4039(01)80146-5

文献信息

• Quinoline derivatives as neurokinin receptor antagonists
  申请人：Carling William Robert

  公开号：US20090054440A1

  公开（公告）日：2009-02-26

  The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

  本发明涉及式(I)所示的取代喹啉酰肼：其中R1、R2、R3、R4、R5、X、Y和Z在此定义，包含它们的药物组合物及其在治疗由神经激肽-2和/或神经激肽-3 (NK-3)受体介导的疾病中的用途。因此，这些化合物可用于治疗方法，以抑制和治疗这些疾病。
• PYRAZOLYL DERIVATIVES AS SYK INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150191461A1

  公开（公告）日：2015-07-09

  The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

  本发明提供了公式I的新型吡唑衍生物，它们是脾酪氨酸激酶的有效抑制剂，并可用于治疗和预防由该酶介导的疾病，如哮喘、慢性阻塞性肺疾病、类风湿性关节炎和癌症。
• Process for producing flexible polyurethane foam having high air flow property
  申请人：Tosoh Corporation

  公开号：EP0451826A2

  公开（公告）日：1991-10-16

  Process for producing a flexible polyurethane foam through reaction of a polyol with a polyisocyanate in the presence of an amine catalyst, a blowing agent, and a foam stabilizer, the amine catalyst comprising at least one of the imidazoles represented by the general formula below: wherein R¹ is alkyl of 1 to 4 carbons, dimethylaminopropyl, benzyl, vinyl, or hydroxyalkyl of 1 to 3 carbons; R² is hydrogen, alkyl of 1 to 4 carbons, allyl, benzyl, or phenyl; and R³ and R⁴ are respectively hydrogen, alkyl of 1 to 4 carbons, or hydroxymethyl.

  在胺催化剂、发泡剂和泡沫稳定剂存在下，通过多元醇与多异氰酸酯反应生产软质聚氨酯泡沫塑料的工艺，胺催化剂包括下式通式所代表的至少一种咪唑： 其中 R¹ 为 1 至 4 个碳原子的烷基、 R¹是 1 至 4 个碳原子的烷基、二甲基氨基丙基、苄基、乙烯基或 1 至 3 个碳原子的羟基烷基；R²是氢、1 至 4 个碳原子的烷基、烯丙基、苄基或苯基；R³ 和 R⁴ 分别是氢、1 至 4 个碳原子的烷基或羟甲基。
• Polycyclic pyridone derivative having integrase inhibitory activity
  申请人：Shionogi & Co., Ltd.

  公开号：US10011613B2

  公开（公告）日：2018-07-03

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

  本发明涉及一种具有抗病毒作用的新型化合物，更具体地说，是一种具有艾滋病病毒整合酶抑制活性的吡啶酮衍生物，以及含有该化合物的药物，特别是抗艾滋病病毒药物。本发明的化合物对病毒，特别是艾滋病毒及其耐药菌株具有整合酶抑制活性和/或细胞增殖抑制活性。因此，本发明化合物可用于预防或治疗整合酶参与的各种疾病、病毒感染（如艾滋病）等。
• Pyridyl substituted indole compounds
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10660877B2

  公开（公告）日：2020-05-26

  Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

  公开了式 (I) N-氧化物化合物或其盐，其中 R1、R2、R3、R4、R5、m、n 和 p 在本文中定义。还公开了使用此类化合物作为通过 Toll 样受体 7 或 8 或 9 信号转导的抑制剂的方法，以及包含此类化合物的药物组合物。这些化合物可用于治疗炎症和自身免疫性疾病。