2-[1-(4-chloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-(1,2-dimethyl-propyl)-acetamide | 1020655-88-2

• 英文名称: 2-[1-(4-chloro-phenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-(1,2-dimethyl-propyl)-acetamide
• 英文别名: 2-[1-(4-chlorophenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-(3-methylbutan-2-yl)acetamide
• CAS: 1020655-88-2
• 化学式: C₂₀H₂₆ClN₃O
• 分子量: 359.899
• InChiKey: WUGZNINLSFFYOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain
  申请人：Merla Beatrix

  公开号：US20080167315A1

  公开（公告）日：2008-07-10

  Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K + channels.

  与公式I对应的替代四氢吡咯吡嗪化合物： 它们的制备方法，包含这些化合物的药物组合物以及利用这些化合物治疗和/或抑制至少部分由KCNQ2/3 K + 通道介导的疼痛和其他疾病或疾病状态的方法。
• SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND/OR INHIBITION OF PAIN
  申请人：MERLA Beatrix

  公开号：US20100004252A1

  公开（公告）日：2010-01-07

  Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K + channels.

  公式I对应的替代四氢吡咯吡嗪化合物：其制备过程，包含这些化合物的制药组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3 K +通道介导的疼痛和其他疾病或疾病状态的用途。
• US7625900B2
  申请人：——

  公开号：US7625900B2

  公开（公告）日：2009-12-01
• US8017772B2
  申请人：——

  公开号：US8017772B2

  公开（公告）日：2011-09-13