1-(1H-imidazol-2-yl)propan-1-ol | 1315060-05-9

• 英文名称: 1-(1H-imidazol-2-yl)propan-1-ol
• CAS: 1315060-05-9
• 化学式: C₆H₁₀N₂O
• mdl: MFCD23724073
• 分子量: 126.16
• InChiKey: DOGKJBGFNMAAMA-UHFFFAOYSA-N

物化性质

• 沸点：
  322.0±25.0 °C(Predicted)
• 密度：
  1.162±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS COOLING AGENTS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE ET LEUR UTILISATION COMME AGENTS DE REFROIDISSEMENT
  申请人：GIVAUDAN SA

  公开号：WO2009089641A1

  公开（公告）日：2009-07-23

  The present invention refers to compounds with cooling properties, the compound are of formula (I), wherein R1 is selected from the list consisting of C1 - C3 alkyl, - SCH3, and - NH2, and - CHR'OR'' wherein R' and R'' are independently selected from hydrogen, methyl and ethyl; R2 is selected from the list consisting of hydrogen, C1 - C3 alkyl, and a halide; and I) A is formula (II) wherein R is selected from hydrogen, -OR11 wherein R11 is selected from hydrogen, and C1-C3 alkyl; halide; -NO2; -CN; -C(O)NH2; and -C(O)OR12 wherein R12 is selected from hydrogen, and C1-C3 alkyl; and X is selected from the list consisting of -CH2-, -C(O) -, and -C(O)NHCH2-; or II) A is formula (III) wherein n is 0 or 1.

  本发明涉及具有冷却性能的化合物，该化合物的化学式为(I)，其中R1从以下列表中选择：C1 - C3烷基，-SCH3，-NH2，和-CHR'OR''，其中R'和R''分别独立地选择自氢，甲基和乙基；R2从以下列表中选择：氢，C1 - C3烷基，和卤素；以及I）A为化学式(II)，其中R从氢，-OR11（其中R11从氢和C1-C3烷基中选择），卤素，-NO2，-CN，-C(O)NH2，和-C(O)OR12（其中R12从氢和C1-C3烷基中选择）中选择；X从以下列表中选择：-CH2-，-C(O)-，和-C(O)NH -；或II）A为化学式(III)，其中n为0或1。
• Preparation of phosphorothioate oligomers
  申请人：McGill University

  公开号：US20040097722A9

  公开（公告）日：2004-05-20

  Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.

  本发明揭示了制备含有对映异构富集的磷酸硫酯键寡聚物的方法和中间体。
• Imidazolylpropanol compounds and their acid addition salts, and production and use thereof
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0054974A1

  公开（公告）日：1982-06-30

  An imidazolyl propanol compound of the formula wherein Ph is a phenyl group or a phenyl group substituted with halogen, and A is -S-R' (wherein R1 is a C1-C15 alkyl group, a phenyl group, a phenyl group substituted with at least one of C1-C8 alkyl. C1-C8 alkoxy and halogen, a benzyl group or a pyridyl group), -O-R2 (wherein R2 is a hydrogen atom, a C1-C15 alkyl group, a C1-C8 alkyl group substituted with at least one of phenylthio and C1-C8 alkylthio, a C3-C8 alkenyl group, a C7-C8 aralkyl group, a C7-C8 aralkyl group substituted with halogen, a phenyl group or a phenyl group substituted with at least one of halogen, C1-C8 alkyl, C1-C8 alkoxy, acetylpiperazino and C1-C8 alkylthio), or (wherein R3 and R4 are each a hydrogen atom, a C1-C8 alkyl group, a C3-C6 cycloalkyl group, a benzyl group, a benzyl group substituted with halogen, a C1-C8 alkyl group substituted with at least one of hydroxyl, morpholino and C1-C8 alkoxy, a C3-C6 alkynyl group, a furfuryl group or a tetrahydrofurfuryl group, or when taken together with the adjacent nitrogen atom, they represent a morhpholino group, a piperazino group, an N-(C1-C8)alkylpiperazino group, an N-phenylpiperazino group, an N-benzylpiperazino group, a pyrrolidino group or a piperidino group), and its acid addition salts, which are useful as'antifungal agents.

  式中的咪唑基丙醇化合物 其中 Ph 是苯基或被卤素取代的苯基，以及 A是-S-R'（其中R1是C1-C15烷基、苯基、被C1-C8烷基、C1-C8烷氧基和卤素中至少一种取代的苯基、苄基或苄基）。C1-C8烷氧基和卤素取代的苯基、苄基或吡啶基）、 -O-R2（其中 R2 为氢原子、C1-C15 烷基、被苯硫基和 C1-C8 烷硫基中至少一种取代的 C1-C8 烷基、C3-C8 烯基、C7-C8 芳基、被卤素取代的 C7-C8 芳基、苯基或被卤素、C1-C8 烷基、C1-C8 烷氧基、乙酰基哌嗪基和 C1-C8 烷硫基中至少一种取代的苯基），或 (其中 R3 和 R4 各为氢原子、C1-C8 烷基、C3-C6 环烷基、苄基、被卤素取代的苄基、被羟基、吗啉基和 C1-C8 烷氧基中至少一种取代的 C1-C8 烷基、C3-C6 炔基、糠基或四氢糠基、或与邻近的氮原子一起代表吗啉基、哌嗪基、N-(C1-C8)烷基哌嗪基、N-苯基哌嗪基、N-苄基哌嗪基、吡咯烷基或哌啶基）及其酸加成盐，可用作 "抗真菌剂"。
• Optically active imidazolylpropanol compounds, and their production and use
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0098942A1

  公开（公告）日：1984-01-25

  An optically active imidazolylpropanol compound of the formula: wherein n is an integer of 3 or 4, and its acid addition salts, which is useful as an antifungal agent.

  一种光学活性咪唑基丙醇化合物，其化学式为 式中 n 为 3 或 4 的整数的光学活性咪唑丙醇化合物及其酸加成盐，可用作抗真菌剂。
• Polyetherester-Polyole und Verfahren zu deren Herstellung
  申请人：BASF SE

  公开号：EP2617748A1

  公开（公告）日：2013-07-24

  Die vorliegende Erfindung betrifft neuartige Polyetherester-Polyole sowie ein Verfahren zu deren Herstellung.

  本发明涉及新型聚醚酯多元醇及其制备工艺。