| 1342298-21-8

• CAS: 1342298-21-8
• 化学式: C₃₀H₆₀Cl₂N₆O₆P₂Pt
• 分子量: 928.777
• InChiKey: PVMLPZWTRMQXFT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 tris-[4-(tetrahydro-1,4-oxazino)methyl]phosphane 以 水 为溶剂， 以83%的产率得到
  参考文献：
  名称：

  Novel complexes of tris(aminomethyl)phosphanes with platinum(II): Structural, spectroscopic, DFT and biological activity studies

  摘要：

  Two new platinum(II) complexes with tris(aminomethyl)phosphanes: [trans-PtCl2{P(CH2N(CH2CH2)(2)-NCH3)(3))(2)] (1Pt) and trans-PtCl2{P(CH2N(CH2CH2)(2)O)(3))(2)] (2Pt) were prepared and characterized with NMR and UV-Vis spectroscopies. Their structures were investigated by X-ray crystallography and DFT methods. TDDFT calculations were employed to interpret the electronic spectra of the complexes. Obtained results are not unequivocal, however population analysis indicate, that the character of HOMO and HOMO-1 orbitals depend strongly on the electron donoring properties of the phosphane ligand. Biological activity of 2Pt complex, which is more stable and more soluble in polar solvents than 1Pt, was examined in vitro on the Vero cell line (IC50 = 12.5 mu M). At higher concentrations it induces apoptosis, probably due to changes of the cell cytoskeleton. Luminescence quenching studies and CD spectroscopy of interactions of 2Pt with HSA and BSA indicate that these albumins bind the complex slightly - without altering their tertiary structures, however HSA interacts with 2Pt noticeably stronger than BSA. It was also found that 2Pt does not cleave supercoiled pUC18 plasmid. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.08.027