dichlorido(eta.6-p-cymene)(5-fluoro-1-methyl isonicotinate)ruthenium(II) | 1380066-55-6

• 英文名称: dichlorido(eta.6-p-cymene)(5-fluoro-1-methyl isonicotinate)ruthenium(II)
• CAS: 1380066-55-6
• 化学式: C₂₁H₂₂Cl₂FN₃O₄Ru
• 分子量: 571.398
• InChiKey: NSQGLWYOHSRUGD-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 5-fluorouracil-1-methyl isonicotinate 以 二氯甲烷 为溶剂， 以75%的产率得到dichlorido(eta.6-p-cymene)(5-fluoro-1-methyl isonicotinate)ruthenium(II)
  参考文献：
  名称：

  Arene-ruthenium(II) complexes containing 5-fluorouracil-1-methyl isonicotinate: Synthesis and characterization of their anticancer activity

  摘要：

  To integrate the respective advantages exhibited by half-sandwich arene-Ru(II) fragments and 5-FU derivatives, a multifunctional ligand that links isonicotinic acid and 5-Fu (5-fluorouracil) through an ester bond for achieving the enhanced effect and an organoruthenium(II) complex containing this ligand were prepared and characterized by standard analytical techniques. The cytotoxicity of these organoruthenium(II) compounds containing 5-fluorouracil-1-methyl isonicotinate against BEL-7402 human cancer cells was moderately improved, which implies synergistic action of 5-Fu and the half-sandwich-structured arene-Ru(II). In addition, the organoruthenium(II) compounds containing isonicotinic acid and methyl isonicotinate are also discussed, and the crystal structure of [(eta(6)-p-cymene)RuCl2(methyl isonicotinate)] (4) was determined; its piano-stool structure is analyzed in this paper. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.02.046