[(2,6-bis((dimethylamino)methyl)-4-methyl phenolate)Zn2(OAc)3(H2O)] | 917752-88-6

• 英文名称: [(2,6-bis((dimethylamino)methyl)-4-methyl phenolate)Zn2(OAc)3(H2O)]
• CAS: 917752-88-6
• 化学式: C₁₉H₃₂N₂O₈Zn₂
• 分子量: 547.252
• InChiKey: QUXZAZDKRSYZQB-UHFFFAOYSA-J

反应信息

• 作为反应物：
  描述：

  [(2,6-bis((dimethylamino)methyl)-4-methyl phenolate)Zn2(OAc)3(H2O)] 以 甲醇 为溶剂， 生成 [(2,6-bis((dimethylamino)methyl)-4-methyl phenolate)2Zn4(μ-OH)2(OH)4]
  参考文献：
  名称：

  Metallo-β-lactamase-Catalyzed Hydrolysis of Cephalosporins: Some Mechanistic Insights into the Effect of Heterocyclic Thiones on Enzyme Activity

  摘要：

  The hydrolysis of beta-lactam antibiotics using zinc-containing metallo-beta-lactamases (m beta l) is one of the major bacterial defense systems. These enzymes can catalyze the hydrolysis of a variety of antibiotics including the latest generation of cephalosporins, cephamycins, and imipenem. It is shown in this paper that the cephalosporins having heterocyclic - SR side chains are less prone to m beta l-mediated hydrolysis than the antibiotics that do not have such side chains. This is partly due to the inhibition of enzyme activity by the thione moieties eliminated during hydrolysis. When the enzymatic hydrolysis of oxacillin was carried out in the presence of heterocyclic thiones such as MU, MDT, DMETT, and MMA, the catalytic activity of the enzyme was inhibited significantly by these compounds. Although the heterocyclic - SR moieties eliminated from the beta-lactams upon hydrolysis undergo a rapid tautomerism between thione and thiol forms, these compounds act as thiolate ligands toward zinc(II) ions. The structural characterization of two model tetranuclear zinc(II) thiolate complexes indicates that the -SR side chains eliminated from the antibiotics may interact with the zinc(II) metal center of m beta l through their sulfur atoms.

  DOI：

  10.1021/ic100253k