[Pd(bpy)(pyr-Ac)]NO₃ | 1443439-65-3

• 英文名称: [Pd(bpy)(pyr-Ac)]NO₃
• 英文别名: [Pd(2,2'-bipyridine)(1-pyrrolacetato)]NO₃
• CAS: 1443439-65-3
• 化学式: C₁₆H₁₅N₃O₂Pd*NO₃
• 分子量: 449.739
• InChiKey: HKJRNDAOSZIMHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [Pd(bpy)(H₂O)₂](NO₃)₂ 、 pyr-AcNa 以 水 为溶剂， 反应 2.0h， 以58%的产率得到[Pd(bpy)(pyr-Ac)]NO₃
  参考文献：
  名称：

  Synthesis, Characterization, and Cytotoxicity Studies of a Novel Palladium(II) Complex and Evaluation of DNA-Binding Aspects

  摘要：

  A new water-soluble palladium(II) complex, [Pd(bpy)(pyr-Ac]NO3 in which bpy = 2,2-bipyridine and pyr-Ac is 1-pyrrolacetato, has been synthesized and characterized by spectroscopic methods (H-1 NMR, FT-IR, and UV-Vis), molar conductivity measurements, and elemental analysis. The results obtained from elemental analysis and conductivity measurements confirmed the stoichiometry of ligand and its complex while the characteristic peaks in UV-Vis and FT-IR and resonance peaks in H-1 NMR spectra confirmed the formation of ligand frameworks around the palladium ion. The 50% cytotoxic concentration (Ic(50)) of new synthesized Pd(II) complex was determined by using MTT assay against human breast cancer cell line, T47D. The interaction between the Pd(II) complex with calf thymus DNA was studied at different temperatures by using absorption spectroscopy, fluorescence titration spectra, ethidium bromide displacement, and gel chromatography studies. The results obtained by absorption spectroscopy revealed that the Pd(II) complex can bind to DNA cooperatively at low concentrations. Several binding parameters in the above interaction were calculated by the fluorescence quenching method. The quenching mechanism was suggested to be the static quenching. The thermodynamic parameters: enthalpy change (H degrees), entropy change (S degrees), and Gibbs free energy (G degrees), showed that van der Waals and hydrogen binding are predominant intermolecular forces between Pd(II) complex and DNA. These results were also consistent with the results obtained from Scatchard's plots.

  DOI：

  10.1080/15257770.2013.790552