[Ru₂(p-cymene)₂(μ₄-(2,5-dioxido-3-undecyl-1,4-benzoquinonato))Cl₂] | 1365124-97-5

• 英文名称: [Ru₂(p-cymene)₂(μ₄-(2,5-dioxido-3-undecyl-1,4-benzoquinonato))Cl₂]
• 英文别名: Ru₂(p-cymene)₂(μ₄-2,5-dioxido-3-undecyl-1,4-benzoquinonato)Cl₂；(η⁶-p-cymene)₂Ru₂(μ₄-embelin)Cl₂；[Ru₂(p-cymene)₂(μ₄-dubq)Cl₂]；Ru₂(p-cymene)₂(μ₄-dubq)Cl₂；(η6-p-cymene)2Ru2(μ-3-undecyl-1,4-benzoquinonato-2,5-diolato-κO)Cl2；[Ru₂(p-cymene)₂(2,5-dioxido-3-undecyl-1,4-benzoquinonato)Cl₂]；[Ru₂(p-cymene)₂(dubq)Cl₂]
• CAS: 1365124-97-5
• 化学式: C₃₇H₅₂Cl₂O₄Ru₂
• 分子量: 833.863
• InChiKey: JSSGFQANOSRQOF-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  2,4,6-三(4-吡啶)1,3,5-三嗪 、 [Ru₂(p-cymene)₂(μ₄-(2,5-dioxido-3-undecyl-1,4-benzoquinonato))Cl₂] 、 silver trifluoromethanesulfonate 以 甲醇 为溶剂， 以87%的产率得到[(η6-p-cymene)6Ru6(μ3-2,4,6-tri(pyridin-4-yl)-1,3,5-triazine-κN)2(μ-3-undecyl-1,4-benzoquinonato-2,5-diolato-κO)3][triflato]6*6H2O
  参考文献：
  名称：

  Physical and Physicochemical Stimuli-Responsive Arene Ruthenium Metallaprism

  摘要：

  A stimuli-responsive metallaprism composed of six p-cymene ruthenium corners bridged by 3-undecyl-1,4-benzoquinonato-2,5-diolato ligands and connected by triangular 2,4,6-tri(pyridin-4-yl)-1,3,S-triazine panels has been synthesized and characterized. In solution, the nature of the solvent and the temperature dictate the conformation of the metallaprism. The alkyl chains can either point away from the metallaprism or hide in the hydrophobic environments of the metallaprism.

  DOI：

  10.1021/om300038g
• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 恩贝酸/恩贝灵 以 甲醇 为溶剂， 以85%的产率得到[Ru₂(p-cymene)₂(μ₄-(2,5-dioxido-3-undecyl-1,4-benzoquinonato))Cl₂]
  参考文献：
  名称：

  Physical and Physicochemical Stimuli-Responsive Arene Ruthenium Metallaprism

  摘要：

  A stimuli-responsive metallaprism composed of six p-cymene ruthenium corners bridged by 3-undecyl-1,4-benzoquinonato-2,5-diolato ligands and connected by triangular 2,4,6-tri(pyridin-4-yl)-1,3,S-triazine panels has been synthesized and characterized. In solution, the nature of the solvent and the temperature dictate the conformation of the metallaprism. The alkyl chains can either point away from the metallaprism or hide in the hydrophobic environments of the metallaprism.

  DOI：

  10.1021/om300038g

文献信息

• Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance
  作者：Ersin Orhan、Amine Garci、Tina Riedel、Mylène Soudani、Paul J. Dyson、Bruno Therrien

  DOI：10.1016/j.jorganchem.2015.12.013

  日期：2016.2

  Tetranuclear arene ruthenium complexes of the general formula [Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom)](4+) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4)-L)Cl-2] (L = diethyl-1,2-diazenedicarboxylato (dadc), oxalato (oxa), bis(2-hydroxyethyl)oxamidato (bho), bis2-(2-hydroxyethoxy)ethyl}ethanediamidato (bhe), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dihydroxy-3-phenyl-1,4-benzoquinonato (dhpb), 2,5-dibromo-1,4-benzoquinonato (dBrbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato (dhdb), 2,5-dihydroxy-3,6-(3,5-dimethylphenyl)-1,4-benzoquinonato (dhdm), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the tetradentate tpom ligand and silver trifluoromethanesulfonate. The antiproliferative activity of the tetranuclear complexes was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing in most cases cancer cell selectivity and, in some cases, low micromolar cytotoxicities (similar to 1 mu M) against a cancer cell line that has acquired resistance to cisplatin. (C) 2015 Elsevier B.V. All rights reserved.
• Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies
  作者：Gajendra Gupta、Patrycja Nowak-Sliwinska、Noelia Herrero、Paul J. Dyson、Bruno Therrien

  DOI：10.1016/j.jorganchem.2015.02.004

  日期：2015.11

  A series of arene ruthenium metalla-rectangles of general formula [(eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-N boolean AND N)(2)](CF3SO3)(4) was prepared from the embelin-derived metalla-clip (eta(6)-p-cymene)(2)Ru-2(mu(4)-embelin) Cl-2 (1), silver triflate and several linear ditopic N-ligands (N boolean AND N); pyrazine (prz), 4,4'-bipyridine (bpy), 1,2-bis(4-pyridyl)ethylene (bpe), 4,4'-azopyridine (azp) and di(pyridin-4-yl)oxalamide (bpo). The anti-proliferative activity of these multinuclear arene ruthenium metalla-rectangles was evaluated in vitro on the human ovarian cancer cells A2780 and A2780cisR and on the noncancerous cell line HEK-293. Among these complexes, two rectangles, [(eta(6)-p-cymene)(4)Ru-4(mu(4)-embelin)(2)(mu(2)-bpy)(2)](CF3SO3)(4) and [(eta(6)-p-cymene) Ru-4(4)(mu(4)-embelin)(2)(mu(2)-bpo)(2)](CF3SO3)(4), display excellent activity and selectivity for cancer cells. (C) 2015 Elsevier B.V. All rights reserved.
• Coordination-driven self-assembly of arene ruthenium metalla-rectangles
  作者：Ersin Orhan、Amine Garci、Bruno Therrien

  DOI：10.1016/j.ica.2017.01.033

  日期：2017.5

  Series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-N boolean AND N)(2) (mu(4)-OO boolean AND OO2][CF3SO3](4) (N boolean AND N = 2,5- dipyridyl-thiophene (dptp), 3,6-dipyridyl-1,2,4,5-tetrazine (dptz), 3,6-dipyridyl-1,4-dihydro-1,2,4,5-tetrazine (dpdt)) were prepared by reacting the dinuclear arene ruthenium complexes Ru-2(p-cymene)(2)(mu(4)-OO boolean AND OO)Cl-2 (OO boolean AND OO = oxalato (oxa), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 5,8-dioxido-1,4-naphtoquinonato (donq)) with silver trifluoromethanesulfonate, followed by the addition of the corresponding N boolean AND N linkers. All metalla-rectangles were characterized by standard techniques, including infrared, UV-visible, H-1, C-13 NMR spectroscopy and ESI mass spectrometry: Thus confirming the rectangular structure of the complexes, and showing the facility of forming tetranuclear arene ruthenium metalla-rectangles. (C) 2017 Elsevier B. V. All rights reserved.
• Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers
  作者：Ersin Orhan、Amine Garci、Tina Riedel、Paul J. Dyson、Bruno Therrien

  DOI：10.1016/j.jorganchem.2016.05.004

  日期：2016.8

  A series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-L)(2)(mu(4)-OO boolean AND OO)(2)][CF3SO3](4) (L-1 = N,N'-bis(4-pyridylmethyl)-pyromellitic diimide, L-2 = N,N'-bis(4-pyridylmethyl)-naphthalene diimide) were obtained from the corresponding dinuclear arene ruthenium complexes Ru-2(p-cymene)(2)(mu 4-OO boolean AND OO)Cl-2 (OO boolean AND OO = oxalato (oxa), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dihydroxy-3-phenyl-1,4-benzoquinonato (dhpb), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato (dhdb), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the bidentate ligands (L-1 and L-2) and silver trifluoromethanesulfonate. The antiproliferative activity of the tetranuclear arene ruthenium metalla-rectangles was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing in all cases cancer cell selectivity. In general, the metalla-rectangles obtained with L-2 are more potent than those incorporating L-1, and with the exception of [Ru-4(p-cymene)(4)(mu(2)-L-1)(2)(m(4)-dClbq)(2)][CF3SO3](4), they are all more active than cisplatin on the cisplatin resistant A2780cisR cell line. (C) 2016 Elsevier B.V. All rights reserved.
• Flexible arene ruthenium metalla-prisms
  作者：Ersin Orhan、Amine Garci、Bruno Therrien

  DOI：10.1016/j.ica.2015.09.002

  日期：2015.11

  Cationic arene ruthenium metalla-prisms of the general formula [Ru-6(p-cymene)(6)(tpmtt)(2)(OO boolean AND OO)(3)](6+) (tpmtt = 1,3,5-tris(pyridin-4-ylmethyl)-1,3,5-triazinane-2,4,6-trione) have been obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(OO boolean AND OO)Cl-2] (OO boolean AND OO = oxalato (ox), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the tridentate tpmtt ligand and silver trifluoromethanesulfonate. These cationic arene ruthenium metalla-prisms have been isolated and characterized as their triflate salts. Upon formation of the metalla-prisms, the two tpmtt panels are in close proximity and do not allow encapsulation of guest molecules. (C) 2015 Elsevier B.V. All rights reserved.