1-cyclohexylmethyl-2-ethoxymethyl-7-(5-hydroxymethylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine | 723269-34-9

• 英文名称: 1-cyclohexylmethyl-2-ethoxymethyl-7-(5-hydroxymethylpyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine
• 英文别名: [5-[4-Amino-1-(cyclohexylmethyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-7-yl]pyridin-3-yl]methanol
• CAS: 723269-34-9
• 化学式: C₂₆H₃₁N₅O₂
• 分子量: 445.564
• InChiKey: OVSIRMINCNPVEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  99.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compositions for stimulation of mammalian innate immune resistance to pathogens
  申请人：The Board of Regents, The University of Texas System

  公开号：US10722573B2

  公开（公告）日：2020-07-28

  Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR composition to the individual.

  本发明的实施方案涉及治疗、抑制或减弱已感染或有感染风险的个体的微生物感染的方法，包括向该个体施用有效量的 StIR 组合物的步骤。
• COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2411521B1

  公开（公告）日：2015-01-14
• METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION
  申请人：The Board of Regents of The University of Texas System

  公开号：EP3538218A2

  公开（公告）日：2019-09-18
• US8883174B2
  申请人：——

  公开号：US8883174B2

  公开（公告）日：2014-11-11
• US9186400B2
  申请人：——

  公开号：US9186400B2

  公开（公告）日：2015-11-17