1-Phenoxy-4-(p-kresyl)butan | 68720-27-4

• 英文名称: 1-Phenoxy-4-(p-kresyl)butan
• 英文别名: 1-Methyl-4-(4-phenoxybutoxy)benzene
• CAS: 68720-27-4
• 化学式: C₁₇H₂₀O₂
• 分子量: 256.345
• InChiKey: HYFQMVFFMOWHMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲酚 生成 1-Phenoxy-4-(p-kresyl)butan
  参考文献：
  名称：

  PAL RAM SEWAK; BOKADIA MISHRI MAL., POL. J. CHEM., 1978, 52, NO 7-8, 1473-1477

  摘要：

  DOI：

文献信息

• EGFR proteolysis targeting chimeric molecules and associated methods of use
  申请人：Arvinas Operations, Inc.

  公开号：US10994015B2

  公开（公告）日：2021-05-04

  The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an E3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effectuate ubiquitination, and therefore, degradation (and inhibition) of the target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作受体酪氨酸激酶（RTK）蛋白的调节剂。特别是，本公开涉及双功能化合物，其一端含有与 E3 泛素连接酶结合的配体，另一端含有与靶蛋白结合的分子，从而使靶蛋白靠近泛素连接酶以实现泛素化，进而降解（和抑制）靶蛋白。本公开内容展示了与靶蛋白降解/抑制相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白聚集或积聚而导致的疾病或失调。
• Pal,R.S.; Bokadia,M.M., Polish Journal of Chemistry, 1978, vol. 52, p. 1473 - 1477
  作者：Pal,R.S.、Bokadia,M.M.

  DOI：——

  日期：——