5-methyl-5-phenyl-3-[(2E)-3-phenylprop-2-enoyl]imidazolidine-2,4-dione | 864501-57-5

• 英文名称: 5-methyl-5-phenyl-3-[(2E)-3-phenylprop-2-enoyl]imidazolidine-2,4-dione
• 英文别名: 5-methyl-5-phenyl-3-[(E)-3-phenylprop-2-enoyl]imidazolidine-2,4-dione
• CAS: 864501-57-5
• 化学式: C₁₉H₁₆N₂O₃
• 分子量: 320.348
• InChiKey: CVUFMDNFBDNMSX-OUKQBFOZSA-N

物化性质

• 密度：
  1.273±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Hydantoins having RNase modulatory activity
  申请人：Olson W. Matthew

  公开号：US20050203156A1

  公开（公告）日：2005-09-15

  The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

  本发明涉及具有RNase H、聚合酶和/或HIV逆转录酶调节活性，特别是抑制活性的咪唑烷酮衍生物。该发明包括咪唑烷酮衍生物、含有这些衍生物的组合物、合成这些衍生物的方法、筛选方法以识别这些衍生物，以及使用这些咪唑烷酮衍生物进行治疗的方法，包括治疗HIV、艾滋病和逆转录病毒相关癌症的方法。
• Hydantoins Having RNase Modulatory Activity
  申请人：Olson Matthew W.

  公开号：US20100063118A1

  公开（公告）日：2010-03-11

  The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

  本发明涉及具有RNase H、聚合酶和/或HIV反转录酶调节活性的咪唑二酮衍生物，特别是具有抑制活性的咪唑二酮衍生物。该发明包括咪唑二酮衍生物、含有该衍生物的组合物、合成该衍生物的方法、筛选识别该衍生物的方法以及使用咪唑二酮衍生物的治疗方法，包括治疗HIV、艾滋病和逆转录病毒相关癌症的方法。
• [EN] HYDANTOINS HAVING RNase MODULATORY ACTIVITY<br/>[FR] HYDANTOINES A ACTIVITE MODULATRICE DE LA RNASE
  申请人：WYETH CORP

  公开号：WO2005090316A1

  公开（公告）日：2005-09-29

  The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the hydantoin derivatives, including the treatment of HIV, AIDS and retrovirus­associated cancer.