[Pt(pNAT)Cl3(water)] | 1007581-35-2

• 英文名称: [Pt(pNAT)Cl3(water)]
• CAS: 1007581-35-2
• 化学式: C₉H₁₁Cl₃N₄O₃PtS
• 分子量: 556.716
• InChiKey: LVMNNPKTTHIWRQ-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  dihydrogen hexachloroplatinate 、 2-(1-(4-nitrophenyl)ethylidene)hydrazinecarbothioamide 、 水 在 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 以77%的产率得到[Pt(pNAT)Cl3(water)]
  参考文献：
  名称：

  Synthesis, spectral characterization and eukaryotic DNA degradation of thiosemicarbazones and their platinum(IV) complexes

  摘要：

  The condensation products of acetophenone (or its derivatives), salicylaldehyde and o-hydroxy-p-methoxybenzophenone with thiosemicarbazide and ethyl- or phenyl-thiosemicarbazide are the investigated thiosemicarbazones. Their reactions with H2PtCl6 produced Pt(IV) complexes characterized by elemental, thermal, mass, IR and electronic spectral studies. The coordination modes were found mononegative bidentate in the acetophenone derivatives and binegative tridentate in the salicylaldehyde derivatives. The complexes were analyzed thermogravimetrically and found highly stable. Some ligands and their complexes were screened against Sarcina sp. and E coli using the cup-diffusion technique. [Pt(oHAT)(OH)Cl] shows higher activity against E. coli than the other compounds. The degradation power of the tested compounds on the calf thymus DNA supports their selectivity against bacteria and not against the human or related eukaryotic organisms. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2007.03.010