4-Methoxybutane-2-sulfonyl chloride | 1250276-93-7

• 英文名称: 4-Methoxybutane-2-sulfonyl chloride
• CAS: 1250276-93-7
• 化学式: C₅H₁₁ClO₃S
• mdl: MFCD16671718
• 分子量: 186.66
• InChiKey: JSEBKXSMYTWRIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOUND CONTAINING TRICYCLIC HETEROARYL GROUP
  申请人：Hangzhou Innogate Pharma Co., Ltd.

  公开号：US20190308993A1

  公开（公告）日：2019-10-10

  A class of compounds containing a tricyclic heteroaryl group is provided. Specifically, a compound of the structure represented by the following formula (I) (each group is as defined in the specification), a pharmaceutical composition containing the compound of the formula (I), and their isotope derivatives, chiral isomers, allosterics, different salts, prodrugs, preparations, etc, are provided. It can effectively inhibit protein kinases (such as EGFR, FAK, SYK, FLT-3, Axl, CDK, JAK, etc.), thereby treating various tumors, non-alcoholic liver disease (NASH), pulmonary fibrosis (IPF), and related variety of diseases.

  提供了一类含有三环杂环基团的化合物。具体来说，提供了结构如下式（I）所代表的化合物（每个基团如规范中定义），含有该式（I）化合物的药物组合物，以及它们的同位素衍生物、手性异构体、变构体、不同盐类、前药、制剂等。它可以有效抑制蛋白激酶（如EGFR、FAK、SYK、FLT-3、Axl、CDK、JAK等），从而治疗各种肿瘤、非酒精性脂肪肝病（NASH）、肺纤维化（IPF）和相关多种疾病。
• Compound containing tricyclic heteroaryl group
  申请人：Hangzhou Innogate Pharma Co., Ltd.

  公开号：US10730887B2

  公开（公告）日：2020-08-04

  A class of compounds containing a tricyclic heteroaryl group is provided. Specifically, a compound of the structure represented by the following formula (I) (each group is as defined in the specification), a pharmaceutical composition containing the compound of the formula (I), and their isotope derivatives, chiral isomers, allosterics, different salts, prodrugs, preparations, etc, are provided. It can effectively inhibit protein kinases (such as EGFR, FAK, SYK, FLT-3, Axl, CDK, JAK, etc.), thereby treating various tumors, non-alcoholic liver disease (NASH), pulmonary fibrosis (IPF), and related variety of diseases.

  本发明提供了一类含有三环杂芳基的化合物。具体来说，本发明提供了下式（I）所代表结构的化合物（各基团如说明书中所定义）、含有式（I）化合物的药物组合物，以及它们的同位素衍生物、手性异构体、异构体、不同的盐、原药、制剂等。它能有效抑制蛋白激酶（如表皮生长因子受体、FAK、SYK、FLT-3、Axl、CDK、JAK等），从而治疗各种肿瘤、非酒精性肝病（NASH）、肺纤维化（IPF）及相关的多种疾病。