[4-(Trifluoromethoxy)phenyl]methanesulfonamide | 1250371-16-4

• 英文名称: [4-(Trifluoromethoxy)phenyl]methanesulfonamide
• CAS: 1250371-16-4
• 化学式: C₈H₈F₃NO₃S
• 分子量: 255.22
• InChiKey: HJHZUVWKKWIBDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 2-oxo-3,4-dihydroquinoline compounds as plant growth regulators
  申请人：Syngenta Participations AG

  公开号：US10392348B2

  公开（公告）日：2019-08-27

  The present invention relates to novel sulfonamide derivatives of formula (I), to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants, improving plant tolerance to abiotic stress (including environmental and chemical stresses), inhibiting seed germination and/or safening a plant against phytotoxic effects of chemicals.

  本发明涉及式（I）的新型磺酰胺衍生物、制备它们的工艺和中间体、包含它们的植物生长调节剂组合物，以及使用它们控制植物生长、提高植物对非生物胁迫（包括环境和化学胁迫）的耐受性、抑制种子萌发和/或使植物免受化学品植物毒性影响的方法。
• Azole amides and amines as alpha v integrin inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10851098B2

  公开（公告）日：2020-12-01

  The present invention provides compounds of Formula (I): (Formula (I)), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

  本发明提供了式 (I) 的化合物： 式（I））或其立体异构体、同系物或药学上可接受的盐或溶液，其中所有变量如本文所定义。 这些化合物是含αv整合素的抑制剂。 本发明还涉及包含这些化合物的药物组合物，以及通过使用这些化合物和药物组合物治疗与含αv整合素失调相关的疾病、紊乱或病症的方法，如病理性纤维化、移植排斥、癌症、骨质疏松症和炎症性疾病。
• 2-OXO-3,4-DIHYDROQUINOLINE COMPOUNDS AS PLANT GROWTH REGULATORS
  申请人：Syngenta Participations AG

  公开号：US20180044297A1

  公开（公告）日：2018-02-15

  The present invention relates to novel sulfonamide derivatives of formula (I), to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants, improving plant tolerance to abiotic stress (including environmental and chemical stresses), inhibiting seed germination and/or safening a plant against phytotoxic effects of chemicals.
• AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20190256513A1

  公开（公告）日：2019-08-22

  The present invention provides compounds of Formula (I): (Formula (I)), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.