[(99)Tc(CO)3(o-N-(nitrophenyl)ethylenediaminediacetic acid(-2H)](1-) | 887604-78-6

• 英文名称: [(99)Tc(CO)3(o-N-(nitrophenyl)ethylenediaminediacetic acid(-2H)](1-)
• CAS: 887604-78-6
• 化学式: C₁₅H₁₃N₃O₉Tc
• 分子量: 478.283
• InChiKey: VHOCCDJZEBEIFC-RCUQKECRSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  fac-triaquatricarbonyltechnetium-99m(1+) 、 N-(2-nitrophenyl)ethylenediamine-N',N'-diacetic acid 以 乙醇 、 水 为溶剂， 生成 [(99)Tc(CO)3(o-N-(nitrophenyl)ethylenediaminediacetic acid(-2H)](1-)
  参考文献：
  名称：

  Ethylenediamine- and propylenediaminediacetic acid derivatives as ligands for the “fac-[M(CO)3]+” core (M=Re, 99mTc)

  摘要：

  The reaction of Re(CO)(5)Cl with o- or p-N-(nitrophenyl)ethylenediaminediacetic acid (H2L1, H2L2) and o- or p-N-(nitrophenyl)propylenediaminediacetic acid (H2L3, H2L4) in methanol leads to the formation of stable anionic [Et3NH][Re(CO)(3)(L)]-H2O complexes 1-4. These compounds have been characterized by means of IR, mass spectrometry, elemental analysis, NMR and conductimetry, as well as X-ray crystallography for 2 and 3. The [Re(CO)(3)](+) moiety is coordinated via the nitrogen of the iminodiacetic acid unit and two oxygens of monodentate carboxylate groups. In each case, the nitro group of the aromatic ring remains uncoordinated. The analogous technetium-99m complexes V and 3' were also prepared quantitatively by the reaction of H2L1 and H2L3, respectively, with the fac-[Tc-99m(CO)(3)(H2O)(3)](+) precursor in ethanol. The corresponding Re and Tc-99m compounds were shown to possess the same structure by means of HPLC studies. The high affinity of these ligands for the Tc(l) or Re(I) core, coupled with the easiness of their derivatization (by reduction of the nitro group in amino group), implies that the utilization of this ligand system to develop target-specific radiopharmaceuticals for diagnosis and therapy is promising. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.02.023