Pt[methyl 2-(5-bromo-2-hydroxybenzylamino)-3-phenylpropanoate]Cl | 1616492-25-1

• 英文名称: Pt[methyl 2-(5-bromo-2-hydroxybenzylamino)-3-phenylpropanoate]Cl
• CAS: 1616492-25-1
• 化学式: C₁₇H₁₇BrClNO₃Pt
• 分子量: 593.764
• InChiKey: HKYUYYNYJZKVST-CKUXDGONSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  5-溴水杨醛 在 sodium tetrahydroborate 、 magnesium sulfate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 64.0h， 生成 Pt[methyl 2-(5-bromo-2-hydroxybenzylamino)-3-phenylpropanoate]Cl
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with reduced amino acid ester Schiff-bases as ligands

  摘要：

  A series of platinum(II) complexes with reduced amino acid esters Schiff-bases as ligands were prepared as potential anticancer agents and characterized by NMR, IR spectroscopy, elemental analysis and molar conductivity. These compounds were tested for their stability and DNA interaction with salmon sperm DNA by ultraviolet spectrum. The cytotoxicities of these complexes were validated against HL-60, BGC-823, Hela, and HepG2 cell lines by the MTT test. The complexes 5e and 5f exhibited better cytotoxic activity than cisplatin against HepG2 and BGC-823 cell lines, respectively. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.04.036