3-[(cyclohexyl)amino]acetyl-4-cyano-(R)-thiazolidine monohydrochloride | 289481-00-1

• 英文名称: 3-[(cyclohexyl)amino]acetyl-4-cyano-(R)-thiazolidine monohydrochloride
• 英文别名: (4R)-3-[2-(cyclohexylamino)acetyl]-1,3-thiazolidine-4-carbonitrile;hydrochloride
• CAS: 289481-00-1
• 化学式: C₁₂H₁₉N₃OS*ClH
• 分子量: 289.829
• InChiKey: SUZSYNULCLKXGH-RFVHGSKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.76
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PYRROLIDINE, THIAZOLIDINE AND OXAZOLIDINE COMPOUNDS WHICH INHIBIT DIPEPTIDYL PEPTIDASE-IV (DPP)<br/>[FR] COMPOSE DE PYRROLIDINE, DE THIAZOLIDINE ET D'OXAZOLIDINE INHIBANT LA DIPEPTIDYL-PEPTIDASE-IV (DPP-IV)
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004111041A1

  公开（公告）日：2004-12-23

  A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X is cyano or H; Y is CH?2#191, O, S, SO or SO?2# Z is (lower)alkylene, and the like; R1 and R2 are linked together to form (lower)alkylene or (lower)alkenylene, and R3 is H, (lower)alkyl or hydroxy; and the like; and the (lower)alkylene formed by R1 and R2 and the like may be substituted which may be substituted.] Compounds of formula (I) inhibit DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.

  化合物的式(I)或其药学上可接受的盐：[其中X是氰基或H; Y是CH?2#191，O，S，SO或SO?2# Z是(较低的)烷基，等等; R1和R2连接在一起形成(较低的)烷基或(较低的)烯基，R3是H，(较低的)烷基或羟基;等等; R1和R2形成的(较低的)烷基和类似物也可以被替代。]式(I)的化合物抑制DPP-IV活性。因此，它们在治疗由DPP-IV介导的疾病，如2型糖尿病方面是有用的。
• Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
  申请人：Guilford Pharmaceuticals, Inc.

  公开号：US20040152745A1

  公开（公告）日：2004-08-05

  The present invention provides the inhibitors of dipeptidyl peptidase IV based upon or including proline or similar moieties. The inhibitors are useful for treating various disorders, including those of the central nervous system and the prostate. Many of the inhibitors can be reversible, and can cross the blood-brain barrier. Methods of making and using the inhibitors and treatment methods also are provided.

  本发明提供了基于或包含脯氨酸或类似基团的二肽基肽酶IV抑制剂。这些抑制剂可用于治疗各种疾病，包括中枢神经系统和前列腺疾病。许多抑制剂可以是可逆的，并且可以穿过血脑屏障。还提供了制备和使用抑制剂以及治疗方法。
• DIPEPTIDYL PEPTIDASE IV INHIBITORS AND METHODS OF MAKING AND USING DIPEPTIDYL PEPTIDASE IV INHIBITORS
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1228061A1

  公开（公告）日：2002-08-07
• EP1228061A4
  申请人：——

  公开号：EP1228061A4

  公开（公告）日：2004-12-15
• US6110949A
  申请人：——

  公开号：US6110949A

  公开（公告）日：2000-08-29