1-{4-[[3-(cyclopropylmethoxy)-4-methoxyphenyl](1,3-thiazol-5-ylmethyl)amino]phenyl}ethanone | 1203593-52-5

• 英文名称: 1-{4-[[3-(cyclopropylmethoxy)-4-methoxyphenyl](1,3-thiazol-5-ylmethyl)amino]phenyl}ethanone
• 英文别名: 1-[4-[3-(cyclopropylmethoxy)-4-methoxy-N-(1,3-thiazol-5-ylmethyl)anilino]phenyl]ethanone
• CAS: 1203593-52-5
• 化学式: C₂₃H₂₄N₂O₃S
• 分子量: 408.521
• InChiKey: YPMOHXYHQVUMIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  79.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PHOSPHODIESTERASE 4 INHIBITORS
  申请人：HOPPER Allen T.

  公开号：US20100029689A1

  公开（公告）日：2010-02-04

  PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R 1 , R 2 , R 3 , and R 4 are as defined herein.

  PDE4抑制是通过新颖的化合物实现的，例如N-取代苯胺和二苯胺类似物。本发明的化合物为Formula I：其中R1、R2、R3和R4如下所定义。
• [EN] PHOSPHODIESTERASE 4 INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIESTÉRASE 4
  申请人：MEMORY PHARM CORP

  公开号：WO2010003084A2

  公开（公告）日：2010-01-07

  PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3, and R4 are as defined herein.