5-(nitrooxy)hexyl 1-chloroethyl carbonate | 1186124-23-1

• 英文名称: 5-(nitrooxy)hexyl 1-chloroethyl carbonate
• 英文别名: 1-Chloroethyl 5-nitrooxyhexyl carbonate
• CAS: 1186124-23-1
• 化学式: C₉H₁₆ClNO₆
• 分子量: 269.682
• InChiKey: HVXDYOVKFFPJGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  90.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• ANGIOTENSIN II RECEPTOR ANTAGONISTS
  申请人：Almirante Nicoletta

  公开号：US20100311800A1

  公开（公告）日：2010-12-09

  The present invention relates to nitrooxyderivatives of angiotensin II receptor antagonists.

  本发明涉及血管紧张素II受体拮抗剂的硝氧衍生物。
• [EN] ANGIOTENSIN II RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES VIS-À-VIS DES RÉCEPTEURS DE L'ANGIOTENSINE II
  申请人：NICOX SA

  公开号：WO2009106470A2

  公开（公告）日：2009-09-03

  The present invention relates to nitrooxyderivatives of angiotensin II receptor antagonist having the general formula (I): where in R is selected f rom the group consisting of (IIa) - (IIk): when R is selected from (Ilk), Y is selected from the group consisting of: 1) -C(O) (CH2) nR5; 2) -C(O)(CH2n-O-CH2-R5; 3) -C(O)-R6 wherein R6 is the following group: when R is selected from (IIa)-(IIh), Y is selected from the group consisting of: 4) -C(R1R2)OC(O)-(CH2)nR5; 5) -C(R1R2)OC(O)O-(CH2)nR5; 6) C(R1R2)OC(O)(CH2)n-O-CH2-R5; 7) C(R1R2)OC(O)O(CH2)n-O-CH2-R5; 8) -C(R1R2)OC(O)-R6 wherein R6 is as above defined; R1 and R2 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is -CH(ONO2)R7; R7 is CH3 or C1-4 alkyl; n is an integer from 1 to 4; or a pharmaceutically acceptable salt thereof.