2-（2,2,3,4,4,4-六氟丁氧基）乙醇 | 63693-10-7

• 中文名称: 2-（2,2,3,4,4,4-六氟丁氧基）乙醇
• 英文名称: 1,1,1,2,3,3-hexafluoro-4-(2'-hydroxy)ethoxybutane
• 英文别名: 2-(2,2,3,4,4,4-Hexafluorobutoxy)ethanol
• CAS: 63693-10-7
• 化学式: C₆H₈F₆O₂
• 分子量: 226.119
• InChiKey: DBCKBJPBDWIANA-UHFFFAOYSA-N

物化性质

• 沸点：
  173.4±40.0 °C(Predicted)
• 密度：
  1.373±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  六氟丙烯 、 乙二醇甲醚 以33%的产率得到2-hydroxy-3,3,4,5,5,5-hexafluoropentyl methyl ether
  参考文献：
  名称：

  自由基化学。第9部分。1氟化聚醚的方法—模型化合物的研究

  摘要：

  使用过氧化物，γ-射线和UV射线，已研究了六氟丙烯与二醚和18-crown-6的自由基加成反应，并获得了单，二和多加合物。已经阐明了影响这些添加的因素，特别是中间自由基的极性特征。18冠6的加合物保留了与碱金属离子络合的能力。

  DOI：

  10.1002/ijch.199900016

文献信息

• INJECTABLE FORMULATION FOR TREATMENT AND PROTECTION OF PATIENTS HAVING AN INFLAMMATORY REACTION OR AN ISCHEMIA-REPERFUSION EVENT
  申请人：University of Zürich

  公开号：EP2459182A1

  公开（公告）日：2012-06-06
• Injectable Formulation for Treatment and Protection of Patients Having an Inflammatory Reaction or an Ischemia-Reperfusion Event
  申请人：ETH ZURICH

  公开号：US20140100278A1

  公开（公告）日：2014-04-10

  The present invention relates to compounds according to formula (I) for medical use. The compounds are particularly suitable for the treatment and/or prevention of a medical condition involving hypoxic, anoxic and/or inflamed mammalian tissue. Furthermore, the invention relates to the use of said compounds for preparing a medicament and to pharmaceutical preparations comprising such compounds. The invention also relates to methods of treating or protecting patients having or being prone to develop a medical condition involving hypoxic, anoxic and/or inflamed mammalian tissue, the methods comprising administration of a therapeutically effective amount of such compounds.
• US9296678B2
  申请人：——

  公开号：US9296678B2

  公开（公告）日：2016-03-29
• [EN] INJECTABLE FORMULATION FOR TREATMENT AND PROTECTION OF PATIENTS HAVING AN INFLAMMATORY REACTION OR AN ISCHEMIA-REPERFUSION EVENT<br/>[FR] FORMULATION INJECTABLE DE TRAITEMENT ET DE PROTECTION DE PATIENTS SOUFFRANT DE RÉACTION INFLAMMATOIRE OU D’UN ÉVÉNEMENT D'ISCHÉMIE-REPERFUSION
  申请人：UNIV ZUERICH

  公开号：WO2011012283A1

  公开（公告）日：2011-02-03

  The present invention relates to compounds according to formula (I) for medical use. The compounds are particularly suitable for the treatment and/or prevention of a medical condition involving hypoxic, anoxic and/or inflamed mammalian tissue. Furthermore, the invention relates to the use of said compounds for preparing a medicament and to pharmaceutical preparations comprising such compounds. The invention also relates to methods of treating or protecting patients having or being prone to develop a medical condition involving hypoxic, anoxic and/or inflamed mammalian tissue, the methods comprising administration of a therapeutically effective amount of such compounds.