| 1508269-24-6

• CAS: 1508269-24-6
• 化学式: C₂₆H₂₇ClN₂O₂Ru*H₂O
• 分子量: 554.051
• InChiKey: UEZIAAKDZDZGOW-UHFFFAOYSA-M

反应信息

• 作为反应物：
  描述：

  六氟磷酸银 、 、 乙腈 反应 24.0h， 以83%的产率得到
  参考文献：
  名称：

  Neutral and Ionic Cycloruthenated 2-Phenylindoles as Cytotoxic Agents

  摘要：

  The synthesis and characterization of two families of cyclometalated Ru(II) complexes with the new (C-sp2,N-indole)(-) motif formed by activation of the C-H bonds of 2-phenylindole ligands of the general formula {(4'-R'-C6H4)-3-NOMe-5-R-2-6-R-3-(C6H2N)}are presented. The novel ruthenacycles show a remarkable cytotoxic activity in MCF7 and MDA-MB231 breast cancer cell lines, which clearly exceeds those of the trans and cis isomers of [PtCl2(L)(DMSO)] derived from the same ligands and even that of cisplatin.

  DOI：

  10.1021/om400941b