| 835875-31-5

• CAS: 835875-31-5
• 化学式: C₁₆H₁₂Cl₂N₂Pt
• 分子量: 498.271
• InChiKey: FWYCHHHCTNRNSE-KMDBKMSFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  (2-pyridyl)methylene(β-naphthyl)amine 、 [PtCl2(cis-cyclooctene)]2 以 二氯甲烷 为溶剂， 以62%的产率得到
  参考文献：
  名称：

  Synthesis, characterization, and cytotoxicities of platinum(II) complexes bearing pyridinecarboxaldimines containing bulky aromatic groups

  摘要：

  Condensation of 2-pyridinecarboxaldehyde with several primary amines containing bulky aryl groups gave the corresponding pyridinecarboxaldimines (N-N'). Addition of these ligands to [PtCl2(coe)](2) (coe = cis-cyclooctene) gave complexes of the type cis-PtCl2(N-N') in moderate yields. The platinum complexes have been examined for their potential cytotoxicities against OV2008 (human ovarian carcinoma) and the analogous cisplatin-resistant cell line C13. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2004.07.039