[CuCl2(N-allyl di(picolyl)amine)] | 1211543-69-9

• 英文名称: [CuCl2(N-allyl di(picolyl)amine)]
• 英文别名: [CuCl2(Aldpa)]
• CAS: 1211543-69-9
• 化学式: C₁₅H₁₇Cl₂CuN₃
• 分子量: 373.772
• InChiKey: GALPGRJIENVQCB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 N,N-bis(pyridin-2-ylmethyl)prop-2-en-1-amine 以 乙醇 为溶剂， 以79%的产率得到[CuCl2(N-allyl di(picolyl)amine)]
  参考文献：
  名称：

  Synthesis, characterization, bioactivities of copper complexes with N-allyl di(picolyl)amine

  摘要：

  Four copper(H) complexes with N-allyl di(picolyl)amine were synthesized and characterized by physico-chemical and spectroscopic methods. The spectrophotometric and fluorescence titration data indicate that the [(Aldpa)Cu(L)](ClO4)(2) (L = dppz, dione, phen) with conjugated aromatic rings as coordinated ligands can be inserted into the base stacks of DNA more deeply than the [(Aldpa)CuCl2]. The copper(H) complexes [(Aldpa)Cu(L)](ClO4)(2) (L = dppz, dione, phen) can inhibit the proliferation of the four cancer cells (Mcf-7, Eca-109, A549 and HeLa) with IC50 0.5-19.2 mu M, which is larger than that (23.2-84.3 mu M) of [(Aldpa)CuCl2], suggesting their inhibiting activities on the four cancer cells are correlated with their DNA-binding properties. However, the selectivity of [(Aldpa)CuCl2] to cancer cells is better than that of the other three complexes [(Aldpa)Cu(L)](ClO4)(2), which indicates the substituents introduced on the secondary amino nitrogen atom of dpa have great contribution to the antitumor activities of these copper(II) complexes. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2009.10.040