5-amino-2-hydroxy-4-methoxy-N-(3-ethynylphenyl)benzamide | 1352440-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-amino-2-hydroxy-4-methoxy-N-(3-ethynylphenyl)benzamide
• 英文别名: 5-amino-N-(3-ethynylphenyl)-2-hydroxy-4-methoxybenzamide
• CAS: 1352440-85-7
• 化学式: C₁₆H₁₄N₂O₃
• 分子量: 282.299
• InChiKey: LLFDZZJGEDWILA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  84.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(氯甲酸基)己炔羧酸乙酯 、 5-amino-2-hydroxy-4-methoxy-N-(3-ethynylphenyl)benzamide 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以60%的产率得到ethyl 7-[5-(N-3-ethynylphenylcarbamoyl)-4-hydroxy-2-methoxy-phenylamino]-7-oxoheptanoate
  参考文献：
  名称：

  Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors

  摘要：

  A novel series of N-aryl salicylamides with a hydroxamic acid moiety at 5-position were synthesized efficiently. Their activities against EGFR kinase and HDACs were evaluated. All compounds displayed inhibitory activity against EGFR and HDACs. The antiproliferative activities of synthesized compounds were evaluated by MTT method against human cancer cell lines A431, A549 and HL-60. Compound 1o showed the most potent inhibitory activity against A431 and A549. Compounds 1k and 1n exhibited higher potency against HL-60 than gefitinib and SAHA. N-Aryl salicylamides with a hydroxamic acid moiety at 5-position is another new HDAC-EGFR dual inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.05.034
• 作为产物：
  描述：

  4-甲氧基水杨酸 在 亚磷酸三苯酯 、 硝酸 、 铁粉 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 反应 15.0h， 生成 5-amino-2-hydroxy-4-methoxy-N-(3-ethynylphenyl)benzamide
  参考文献：
  名称：

  Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors

  摘要：

  A novel series of N-aryl salicylamides with a hydroxamic acid moiety at 5-position were synthesized efficiently. Their activities against EGFR kinase and HDACs were evaluated. All compounds displayed inhibitory activity against EGFR and HDACs. The antiproliferative activities of synthesized compounds were evaluated by MTT method against human cancer cell lines A431, A549 and HL-60. Compound 1o showed the most potent inhibitory activity against A431 and A549. Compounds 1k and 1n exhibited higher potency against HL-60 than gefitinib and SAHA. N-Aryl salicylamides with a hydroxamic acid moiety at 5-position is another new HDAC-EGFR dual inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.05.034

文献信息

• PROCESS FOR DYEING IN THE PRESENCE OF OXIDATION BASES COMPRISING AT LEAST ONE SULFONIC, SULFONAMIDE, SULFONE, AMID OR ACID GROUP AND A METAL CATALYST, DEVICE AND READY-TO-USE COMPOSITION
  申请人：L'OREAL

  公开号：US20160143826A1

  公开（公告）日：2016-05-26

  The present invention relates to a process for dyeing human keratin fibres, in which use is made of one or more metal catalysts and a composition (A) comprising: (a) at least 10% by weight of one or more fatty substances, (b) one or more oxidation bases of formula (I) or (II), the addition salts thereof, solvates thereof and mixtures thereof: Formula (I), Formula (II) (c) one or more chemical oxidizing agents other than atmospheric oxygen. The invention also relates to a multi-compartment device and to a composition comprising all of the above-mentioned ingredients.
• US9872822B2
  申请人：——

  公开号：US9872822B2

  公开（公告）日：2018-01-23