(4-((4-nitrophenyl)amino)-4-oxobutyl)triphenylphosphonium chloride | 1030608-31-1

• 英文名称: (4-((4-nitrophenyl)amino)-4-oxobutyl)triphenylphosphonium chloride
• CAS: 1030608-31-1
• 化学式: C₂₈H₂₆N₂O₃P*Cl
• 分子量: 504.953
• InChiKey: CLOGQEICMBOJPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.31
• 重原子数：
  35.0
• 可旋转键数：
  9.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72.24
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  三苯基膦 、 N-(4'-nitrophenyl)-4-chlorobutanamide 以39.8%的产率得到(4-((4-nitrophenyl)amino)-4-oxobutyl)triphenylphosphonium chloride
  参考文献：
  名称：

  Anticancer activities of some arylcarbamoylalkyltriphenylphosphonium chlorides

  摘要：

  A series of novel arylcarbamoylalkyltriphenylphosphonium chlorides were synthesized. The newly synthesized compounds, [R-(p-C6H4)-NH-CO-R1P circle plus (C6H4)(3)] C1(theta), R = H (2), CH3 (4), NO2 (6), R-1 = -CH2-(b), CH3CH<(a), -CH2CH2- (c), -CH2CH2CH2 (d), the analogs of an anticancer drug, were characterized by infrared (IR), H-1 nuclear magnetic resonance (NMR), C-13-NMR, (PNMR)-P-31, mass spectrometry ( MS), thermogravimetry ( TG), and conductivity measurements. The anticancer activities of the obtained compounds were measured by MTT. The preliminary results indicated that some compounds showed potent anticancer activities against HCT-8, Bel-7402, A549, and S180.

  DOI：

  10.1007/s00044-007-9050-7