N6-(ferrocenmethyl)quinazolin-2,4,6-triamine | 1342804-62-9

• 英文名称: N6-(ferrocenmethyl)quinazolin-2,4,6-triamine
• 英文别名: N⁶-(ferrocenmethyl)quinazolin-2,4,6-triamine；N6-(ferrocenmethyl)quinazoline-2,4,6-triamine
• CAS: 1342804-62-9
• 化学式: C₁₉H₁₉FeN₅
• 分子量: 373.24
• InChiKey: HGBGZUZUSDOPRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  N-{2-(acetylamino)-6-[(ferrocenmethyl)amin]quinazolin-4-yl}acetamide 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以62%的产率得到N6-(ferrocenmethyl)quinazolin-2,4,6-triamine
  参考文献：
  名称：

  N6-(FERROCENMETHYL)QUINAZOLIN-2,4,6-TRIAMINA (H2) AND THE DERIVATIVES AND PRODRUGS THEREOF AS ANTILEISHMANIAL, ANTIPROTOZOAL, ANTIPARASITIC AND ANTIMICROBIAL AGENTS

  摘要：

  使用N6-(ferrocenmethyl)quinazoline-2,4,6-triamine（H2）及其衍生物和前药，具有抗微生物（抗生素，微生物杀灭剂），抗寄生虫（寄生虫杀灭剂），抗原虫（原虫杀灭剂）和抗利什曼病（利什曼菌杀灭剂）活性，并将其用作脊椎动物（人类和动物）的药物。

  公开号：

  US20130109663A1

文献信息

• Antileishmanial activity of quinazoline derivatives: Synthesis, docking screens, molecular dynamic simulations and electrochemical studies
  作者：Cesar Mendoza-Martínez、Norma Galindo-Sevilla、José Correa-Basurto、Victor Manuel Ugalde-Saldivar、Rosa Georgina Rodríguez-Delgado、Jessica Hernández-Pineda、Cecilia Padierna-Mota、Marcos Flores-Alamo、Francisco Hernández-Luis

  DOI：10.1016/j.ejmech.2014.12.051

  日期：2015.3

  A series of quinazoline-2,4,6-triamine were synthesized and evaluated in vitro against Leishmania mexicana. Among them, N-6-(ferrocenmethyl)quinazolin-2,4,6-triamine (II2) showed activity on promastigotes and intracellular amastigotes, as well as low cytotoxicity in mammalian cells. Docking and electrochemical studies showed the importance of both the ferrocene and the heterocyclic nucleus to the observed activity. 142 is readily oxidized electrochemically, indicating that the mechanism of action probably involves redox reactions. (C) 2014 Elsevier Masson SAS. All rights reserved.
• N6-(FERROCENMETHYL)QUINAZOLIN-2,4,6-TRIAMIN (H2) AND THE DERIVATIVES AND PRODRUGS THEREOF AS ANTILEISHMANIAL, ANTIPROTOZOAL, ANTIPARASITIC AND ANTIMICROBIAL AGENTS
  申请人：Galindo Sevilla, Norma Del Carmen

  公开号：EP2599783B1

  公开（公告）日：2016-12-14