dichloro(propylenediamine-N,N'-diacetic acid) platinum(II) | 1591642-08-8

• 英文名称: dichloro(propylenediamine-N,N'-diacetic acid) platinum(II)
• CAS: 1591642-08-8
• 化学式: C₇H₁₄Cl₂N₂O₄Pt
• 分子量: 456.185
• InChiKey: ANFCNJPDWMOKJP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  dichloro(propylenediamine-N,N'-diacetic acid) platinum(II) 在 silver sulfate 、 barium hydroxide octahydrate 作用下， 以 水 为溶剂， 以79%的产率得到(propylenediamine-N,N'-diacetic acid) platinum(II)
  参考文献：
  名称：

  Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity

  摘要：

  Two Pt(II) complexes of propylenediamine-N,N '-diacetic acid (H(2)pdda) have been synthesized in which H(2)pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N2O4)Cl-2] (1) and [Pt(C7H12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N2O4)]center dot 3H(2)O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.

  DOI：

  10.1080/00958972.2014.900550
• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 1,3-二氨基丙烷-N,N'-二乙酸 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 7.0h， 以63.9%的产率得到dichloro(propylenediamine-N,N'-diacetic acid) platinum(II)
  参考文献：
  名称：

  Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity

  摘要：

  Two Pt(II) complexes of propylenediamine-N,N '-diacetic acid (H(2)pdda) have been synthesized in which H(2)pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N2O4)Cl-2] (1) and [Pt(C7H12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N2O4)]center dot 3H(2)O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.

  DOI：

  10.1080/00958972.2014.900550