(η6-p-cymene)[N-(2-bromo-5,11-dihydroindolo[3,2-c]quinolin-6-ylidene)-κN'-(1-κN-pyridin-2-yl-ethylidene)]azinechloridoosmium(II) chloride | 1262329-06-5

• 英文名称: (η6-p-cymene)[N-(2-bromo-5,11-dihydroindolo[3,2-c]quinolin-6-ylidene)-κN'-(1-κN-pyridin-2-yl-ethylidene)]azinechloridoosmium(II) chloride
• CAS: 1262329-06-5
• 化学式: C₃₂H₃₀BrClN₅Os*Cl
• 分子量: 825.634
• InChiKey: LIQWAIXJWAEMIR-UWMOSDGTSA-L

反应信息

• 作为产物：
  描述：

  [osmium(II)dichloride(η6-p-cymene)]2 、 N-(2-bromo-5,11-dihydroindolo[3,2-c]quinolin-6-ylidene)-N'-(1-pyridin-2-yl-ethylidene)azine 以 乙醇 为溶剂， 以88%的产率得到(η6-p-cymene)[N-(2-bromo-5,11-dihydroindolo[3,2-c]quinolin-6-ylidene)-κN'-(1-κN-pyridin-2-yl-ethylidene)]azinechloridoosmium(II) chloride
  参考文献：
  名称：

  Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity

  摘要：

  The synthesis of new modified indolo[3,2-c]quinoline ligands L-1-L-8 with metal-binding sites is reported. By coordination to ruthenium- and osmium-arene moieties 16 complexes of the type [(eta(6)-p-cymene)M(L)Cl]Cl (1a,b-8a,b), where M is Ru-II or Os-II and L is L-1-L-8, have been prepared. All compounds were comprehensively characterized by elemental analysis, electrospray ionization mass spectrometry, IR, UV-vis, and NMR spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction (2a, 4a, 4b, 5a, 7a, and 7b). The complexes were tested for antiproliferative activity in vitro in three human cancer cell lines, namely, CH1 (ovarian carcinoma), SW480 (colon adenocarcinoma), and A549 (non-small-cell lung cancer), yielding IC50 values in the submicromolar or low micromolar range.

  DOI：

  10.1021/om101004z