| 208600-09-3

• 英文别名: cis,cis-[Pt2Cl2(NH3)4(μ-H2N(CH2)6NH2)](2+)
• CAS: 208600-09-3；146237-53-8；145375-67-3
• 化学式: C₆H₂₈Cl₂N₆Pt₂
• 分子量: 645.395
• InChiKey: XSBRRZHUKOKRSD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  N-乙酰-L-蛋氨酸 、   生成 [Pt2(NH3)2(μ-H2N(CH2)6NH2)(N-acetyl-L-methionine)4](2+)
  参考文献：
  名称：

  Dinuclear Platinum Complexes with Biological Relevance Based on the 1,2-Diaminocyclohexane Carrier Ligand

  摘要：

  The synthesis of bifunctional dinuclear platinum complexes, [{PtCl-(dach)} (2)-mu-Y]Cl-n+(n) (1-3;Y = H2N(CH2)(3)NH2(CH2)(4)NH2, H2N(CH2)(6)NH2(CH2) 6NH2, and H2N(CH2)(6)NH2(CH2)(2)NH2(CH2)(6)NH2, respectively; Figure 1) is reported. There was no labilization of the polyamine linker groups of the cis-1,2-diaminocyclohexane complexes in the presence of sulfur-containing species at physiological pH, in contrast to previous studies preformed on trans complexes. Metabolism reactions are somewhat dependent on the nature of the polyamine: at physiological pH, the spermidine complex 1 forms an inert (tetraamine) platinum species in which one platinum is chelated by a central and terminal amino group. The stability of cis-geometry complexes may make them viable second-generation polynuclear platinum clinical candidates.

  DOI：

  10.1021/ic700410y