(η⁵-C₅H₅)W(CO)₃(η¹-N-maleimidato) | 868247-75-0

• 英文名称: (η⁵-C₅H₅)W(CO)₃(η¹-N-maleimidato)
• 英文别名: [(η5-cyclopentadienyl)W(CO)3(η1-N-maleimidato)]；(η5-C5H5)W(CO)3(η1-C4H2NO2)；(C5H5)W(carbonyl)3(N-maleimidate)
• CAS: 868247-75-0
• 化学式: C₁₂H₇NO₅W
• 分子量: 429.041
• InChiKey: BKWNTJGAGZHPTH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (η⁵-C₅H₅)W(CO)₃(η¹-N-maleimidato) 、 环戊二烯 以 二氯甲烷 为溶剂， 以51%的产率得到
  参考文献：
  名称：

  用（η的环戊二烯和电子结构Diels-Alder反应5 -环戊二烯基）M（CO）X（η 1 - ñ -maleimidato）（M =铁，钼，钨，X  = 2或3）

  摘要：

  （η的Diels-Alder反应5 -环戊二烯基）M（CO）X（η 1 - ñ -maleimidato）络合物（M =铁，钼，钨，X  = 2或3）与环戊二烯进行了研究。观察到的反应顺序为：N-乙基马来酰亚胺> W络合物> Mo络合物> Fe络合物。对于M ＝ W和Fe，已经确定了加合物的X射线结构。已对起始配合物进行了DFT计算，以解释观察到的反应顺序。

  DOI：

  10.1016/j.jorganchem.2008.12.031

文献信息

• Synthesis of metallocarbonyl substituted 1,2,3-triazole complexes via copper(I)-catalyzed azide–alkyne cycloaddition
  作者：Bogna Rudolf

  DOI：10.1139/v10-107

  日期：2010.10

  (η⁵-C₅H₅)M(CO)_x(η¹-N-maleimidato) (M = Fe, x = 2; M = W, x = 3) complexes react with propargylamine and propargyl alcohol giving products from the Michael addition to the η¹-N-maleimidato ligand. Metallocarbonyl compounds bearing a terminal alkyne group were reacted with organic azides affording corresponding 1,2,3-triazoles in high yields. One of these metallocarbonyl 1,2,3-triazoles (M = Fe, x = 2) was characterized by X-ray diffraction.

  (η5-C5H5)M(CO)x(η1-N-马来酰亚胺)（M = Fe，x = 2；M = W，x = 3）配合物与丙炔胺和丙炔醇发生反应，生成与 η1-N-马来酰亚胺配体发生迈克尔加成反应的产物。带有末端炔基的金属羰基化合物与有机叠氮化物发生反应，可以高产率得到相应的 1,2,3-三唑。这些金属羰基 1,2,3-三唑（M = Fe，x = 2）中的一种通过 X 射线衍射进行了表征。
• The phospha-Michael addition of dimethyl- and diphenylphosphites to the η1-N-maleimidato ligand: Inhibition of serine hydrolases by half-sandwich metallocarbonyl azaphosphonates
  作者：Bogna Rudolf、Michèle Salmain、Marcin Palusiak、Janusz Zakrzewski

  DOI：10.1016/j.jorganchem.2008.10.057

  日期：2009.3

  Dialkyl- and diphenyl phosphites react with the (eta(5)-C5H5)(x)(CO)(x)(eta(1)-N-maleimidato) (M = Fe, Mo; x = 2 or 3) complexes giving products of the phospha-Michael addition to the eta(1)-N-maleimidato ligand. One of these complexes (M=Fe, x=2) was characterized by X-ray diffraction. The synthesized metallocarbonyl azaphosphonates and the corresponding iron phosphonic acid act as inhibitors of certain serine hydrolases (AChE and BChE). The kinetic assays were performed and revealed that inhibition mechanism depends strongly on the enzyme and the structure of the inhibitor. (C) 2008 Elsevier B. V. All rights reserved.
• Oxa-Michael reaction of metallocarbonyl complexes bearing the maleimidato ligand. Reactivity studies with selected hydroxy compounds
  作者：Aleksandra Kubicka、Emilia Fornal、Agnieszka B. Olejniczak、Agnieszka J. Rybarczyk-Pirek、Sławomir Wojtulewski、Bogna Rudolf

  DOI：10.1016/j.poly.2016.01.012

  日期：2016.3