[PdCl((2-diphenylphosphino-benzylidene)-thiophen-3-ylmethyl-amine-N,P)] | 1338578-13-4

• 英文名称: [PdCl((2-diphenylphosphino-benzylidene)-thiophen-3-ylmethyl-amine-N,P)]
• CAS: 1338578-13-4
• 化学式: C₂₄H₂₀Cl₂NPPdS
• 分子量: 562.795
• InChiKey: GPVUJDXMQZSWPN-YWCDJFPNSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-噻吩甲胺 在 magnesium sulfate 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 [PdCl((2-diphenylphosphino-benzylidene)-thiophen-3-ylmethyl-amine-N,P)]
  参考文献：
  名称：

  半不稳定的亚氨基膦钯（II）配合物：合成，分子结构和Heck反应中的评估。

  摘要：

  由2-（二苯基膦基）苯甲醛和噻吩胺制备了2-（二苯基膦基）苄基-（2-噻吩）甲基亚胺（V）和2-（二苯基膦基）苄基-（2-噻吩）乙基亚胺（VI）产量。V和VI与PdCl 2（cod）（cod =环辛二烯）或PdClMe（cod）等摩尔反应，得到钯（II）配合物I–IV。II的分子结构通过X射线晶体学确认。钯原子周围的配位几何在钯中心呈现出扭曲的方形平面几何形状。配合物I，II和IV被评估为在温和的反应条件下碘代苯与丙烯酸甲酯的Heck偶联反应的催化剂; 催化剂：0.1摩尔％，Et 3 N碱，MeCN，80℃回流8小时；用催化剂I（64％），II（68％）和IV（58％）在10 mmol规模上分离得到的产率。他们都表现出重大的活动。

  DOI：

  10.2478/s11696-013-0530-6

文献信息

• Synthesis, characterisation and in vitro evaluation of palladium(II) iminophosphine complexes for anticancer activity
  作者：Haleden Chiririwa、John R. Moss、Denver Hendricks、Reinout Meijboom、Alfred Muller

  DOI：10.1007/s11243-012-9674-4

  日期：2013.3

  Palladium(II) complexes have been obtained from the reactions of the iminophosphine ligands, (L1–L7), respectively, with [PdCl2(COD)] and [PdMeCl(COD)] in CH2Cl2 at room temperature. The palladium(II) complexes were characterised using elemental analysis, electro spray ionisation–mass spectrometry (ESI–MS), NMR (1H and 31P), IR spectroscopy and X-ray diffraction studies. Single-crystal X-ray diffraction analysis for complexes 2, 7 and 8 revealed that the complexes exhibited a slightly distorted square planar geometry. In vitro cytotoxic study results show that the palladium complexes exhibit moderate activity and block the proliferation of WHCO1 cells with an IC50 range of 19.02–45.27 μM, and IC50 range of 10.03–68.54 μM for the KYSE450 cell lines.

  室温下，亚氨基膦配体（L1-L7）分别与[PdCl2(COD)]和[PdMeCl(COD)]在CH2Cl2中发生反应，得到了钯(II)配合物。利用元素分析、电喷雾电离质谱、核磁共振（1H 和 31P）、红外光谱和 X 射线衍射研究对这些钯（II）配合物进行了表征。络合物 2、7 和 8 的单晶 X 射线衍射分析表明，这些络合物呈现出略微扭曲的方形平面几何形状。体外细胞毒性研究结果表明，钯配合物具有中等活性，能阻断 WHCO1 细胞的增殖，其 IC50 范围为 19.02-45.27 μM，对 KYSE450 细胞株的 IC50 范围为 10.03-68.54 μM。
• Neutral palladium(II) complexes with P,N Schiff-base ligands: Synthesis, characterization and catalytic oligomerisation of ethylene
  作者：Mokgolela M. Mogorosi、Tebello Mahamo、John R. Moss、Selwyn F. Mapolie、J. Chris Slootweg、Koop Lammertsma、Gregory S. Smith

  DOI：10.1016/j.jorganchem.2011.07.042

  日期：2011.11

  New N-functionalised 2-phosphinobenzaldimino (P boolean AND N) ligands bearing 3-picolyl, furfuryl, thiophene-2-methyl, thiophene-2-ethyl, and benzyl groups have been prepared in good yield. The 2-phosphinobenzaldimino ligands were reacted with PdCl2(COD) to give the corresponding metal complexes of the type Pd(L)Cl-2 (L = 2-phosphinobenzaldimino (P boolean AND N) ligand). All compounds were fully characterized using spectroscopic and analytical techniques, including H-1, C-13, and P-31 NMR and IR spectroscopies, mass spectrometry and elemental analysis. Selected neutral palladium complexes were evaluated as catalyst precursors in ethylene oligomerisation reactions, after activation with a co-catalyst (MMAO, EtAlCl2, or Et2AlCl). (C) 2011 Elsevier B.V. All rights reserved.