反式-4-甲基吡咯烷-3-醇盐酸盐 | 265108-42-7

• 中文名称: 反式-4-甲基吡咯烷-3-醇盐酸盐
• 英文名称: trans-4-Methylpyrrolidin-3-ol hydrochloride
• 英文别名: (3R,4S)-4-methylpyrrolidin-3-ol;hydrochloride
• CAS: 265108-42-7
• 化学式: C5H12ClNO
• 分子量: 137.61
• InChiKey: VBEGDUJNLVSIES-FHAQVOQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.01
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• PYRAZOL DERIVATIVES
  申请人：Aebi Johannes

  公开号：US20090029963A1

  公开（公告）日：2009-01-29

  The invention is concerned with novel pyrazol derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , X and Y are as defined herein, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor and/or CCR-5 receptor and can be used as medicaments.

  这项发明涉及式(I)的新型吡唑衍生物， 其中 R 1 ，R 2 ，R 3 ，R 4 ，X和Y如本文所定义，以及其生理上可接受的盐。这些化合物是CCR-2受体和/或CCR-5受体的拮抗剂，可用作药物。
• Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV)
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US11339165B2

  公开（公告）日：2022-05-24

  The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).

  本发明涉及具有抗病毒活性的化合物，尤其是对呼吸道合胞病毒（RSV）的复制具有抑制活性的化合物。本发明还涉及包含这些化合物的药物组合物以及用于治疗呼吸道合胞病毒感染的化合物。式 (Ia).
• NEW PYRAZOL DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2182953A2

  公开（公告）日：2010-05-12
• PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US20200361942A1

  公开（公告）日：2020-11-19

  The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).
• US7977358B2
  申请人：——

  公开号：US7977358B2

  公开（公告）日：2011-07-12