cis-[PtCl2(HN=C(NMe2)ONC(Me)NH2] | 1374586-30-7

• 英文名称: cis-[PtCl2(HN=C(NMe2)ONC(Me)NH2]
• CAS: 1374586-30-7
• 化学式: C₅H₁₂Cl₂N₄OPt
• 分子量: 410.162
• InChiKey: YMIKLSNIWCDTDU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  以 硝基甲烷 为溶剂， 反应 72.0h， 以76%的产率得到cis-[PtCl2(HN=C(NMe2)ONC(Me)NH2]
  参考文献：
  名称：

  Amidrazone Complexes from a Cascade Platinum(II)-Mediated Reaction between Amidoximes and Dialkylcyanamides

  摘要：

  The aryl amidoximes R'C6H4C(NH2)=NOH (R' = Me, 2a; H, 2b; CN, 2c; NO2, 2d) react with the dialkylcyanamide platinum(II) complexes trans-[PtCl2(NCNAlk(2))(2)] (Alk(2) = Me-2, 1a; C5H10, 1b) in a 1:1 molar ratio in CHCl3 to form chelated mono addition products [3a-h]Cl, viz. [PtCl-(NCNAlk(2)){(N) under barH=C(NR2)O (N) under bar =C(C6H4R')NH2}]Cl (Alk(2) = Me-2; R' = Me, a; H, b; CN, c; NO2, d; Alk(2) = C5H10; R' = Me, e; H, f; CN, g; NO2, h). In the solution, these species spontaneously transform to the amidrazone complexes [PtCl2{(N) under barH=C(NR2)NC(C6H4R')(N) under barH(2)}] (7a h; 36-47%); this conversion proceeds more selectively (49-60% after column chromatography) in the presence of the base (PhCH2)(3)N. The observed reactivity pattern is specific for NCNAlk(2) ligands, and it is not realized for conventional alkyl- and arylnitrile ligands. The mechanism of the cascade reaction was studied by trapping the isocyanate intermediates [PtCl(NCO){(N) under barH=C(NR2)NC(C6H4R')(N) under bar NH2}] (5a-h) and also by ESI-MS identification of the ammonia complexes [PtCl(NH3)(N) under barH=C(NR2)NC(C6H4R')(N) under bar NH2)](+) ([6a-h]) in solution. The complexes [3a]Cl, [3c-h]Cl, 5a-h and 7ah- were characterized by elemental analyses, high resolution ESI-MS, IR, and H-1 NMR, techniques, while 5b, 5d, 5g, 7b, and 7e were also studied using single crystal X-ray diffraction.

  DOI：

  10.1021/ic4000878

文献信息

• Amidoximes Provide Facile Platinum(II)-Mediated Oxime–Nitrile Coupling
  作者：Dmitrii S. Bolotin、Nadezhda A. Bokach、Matti Haukka、Vadim Yu. Kukushkin

  DOI：10.1021/ic3006019

  日期：2012.5.21

  amidoximes R′C(NH2)═NOH [R′ = Me (2.Me), Ph (2.Ph)] to coordinated nitriles in the platinum(II) complexes trans-[PtCl2(RCN)2] [R = Et (1t.Et), Ph (1t.Ph), NMe2 (1t.NMe2)] and cis-[PtCl2(RCN)2] [R = Et (1c.Et), Ph (1c.Ph), NMe2 (1c.NMe2)] proceeds in a 1:1 molar ratio and leads to the monoaddition products trans-[PtCl(RCN)HN═C(R)ONC(R′)NH2}]Cl [R = NMe2; R′ = Me ([3a]Cl), Ph ([3b]Cl)], cis-[PtCl2HN═C(R)ONC(R′)NH2}]

  mid胺肟R'C（NH 2）═NOH[R'= Me（2.Me），Ph（2.Ph）]亲核加成到反式-[PtCl 2（RCN）的铂（II）配合物中的配位腈2 ] [R = Et（1t.Et），Ph（1t.Ph），NMe 2（1t.NMe 2）]和顺式-[PtCl 2（RCN）2 ] [R = Et（1c.Et），Ph （1c.Ph），NMe 2（1c.NMe 2）]以1：1的摩尔比进行反应，并导致单加成产物反式- [氯铂酸（RCN）H Ñ = C（R）O Ñ C（R'）NH 2 }]氯[R = NME 2 ; R'=我（[ 3A ] Cl）的中，Ph（[图3b ] Cl）的]，顺式- [氯铂酸2 H Ñ = C（R）O Ñ C（R'）NH 2 }] [R = NME 2 ; R'=我（图4a）中，Ph（4B）]，和反式/顺式- [氯铂酸2（RCN）H Ñ = C（R（R）ONC'）NH 2