[(η5-C5Me5)Rh(2-(pyridine-2-yl)thiazole)Cl]Cl | 1228044-65-2

• 英文名称: [(η5-C5Me5)Rh(2-(pyridine-2-yl)thiazole)Cl]Cl
• 英文别名: [(η5-C5Me5)Rh(pyTz)Cl]Cl
• CAS: 1228044-65-2
• 化学式: C₁₈H₂₁ClN₂RhS*Cl
• 分子量: 471.256
• InChiKey: XXHZSPZAYIKGLP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-(2-吡啶基)噻唑 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 以 二氯甲烷 为溶剂， 以85%的产率得到[(η5-C5Me5)Rh(2-(pyridine-2-yl)thiazole)Cl]Cl
  参考文献：
  名称：

  Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand

  摘要：

  The dinuclear dichloro complexes [(eta(6)-arene)(2)Ru-2(mu-Cl)(2)Cl-2] and [(eta(5)-C5Me5)(2)M-2(mu-Cl)(2)Cl-2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(eta(6)-arene)Ru(pyTz)Cl](+) (arene = C6H6 1, p-(PrC6H4Me)-Pr-i 2 or C6Me6 3) and [(eta(5)-C5Me5)M(pyTz)Cl](+) (M = Rh 4 or Ir 5), isolated as the chloride salts. The reaction of 2 and 3 with SnCl2 leads to the dinuclear heterometallic trichlorostannyl derivatives [(eta(6)-p-(PrC6H4Me)-Pr-i)Ru(pyTz)(SnCl3)](+) (6) and [(eta(6)-C6Me6)Ru(pyTz)(SnCl3)](+) (7), respectively, also isolated as the chloride salts. The molecular structures of 4, 5 and 7 have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The in vitro anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.01.020