[RuCl(p-cymene)(1,2-bis(ethylsulfinyl)ethane)]PF6 | 658044-16-7

• 英文名称: [RuCl(p-cymene)(1,2-bis(ethylsulfinyl)ethane)]PF6
• CAS: 658044-16-7
• 化学式: C₁₆H₂₈ClO₂RuS₂*F₆P
• 分子量: 598.016
• InChiKey: WAWFTVAKFQALQZ-GBVANTOISA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  ammonium hexafluorophosphate 、 [(RuCl2(p-cymene))2(μ-1,2-bis(ethylsulfinyl)ethane)] 以 水 为溶剂， 生成 [RuCl(p-cymene)(1,2-bis(ethylsulfinyl)ethane)]PF6
  参考文献：
  名称：

  The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand

  摘要：

  Two diruthenium(II) complexes [RuCl2(p-cymene)](2)(mu-BESE) (1), [RuCl2(p-cymene)](2)(mu-BESP) (2), and the mononuclear salt [RuCl(p-cymene)(BESE)]PF6 (3), containing the disulfoxides BESE and BESP, were synthesized and characterized by elemental analysis, and NMR and IR spectroscopies, and were shown to contain S-bound sulfoxide groups; the disulfoxides are EtS(O)(CH2)(n) S(O)Et, where n = 2 (BESE) or 3 (BESP). Complexes 1 and 3 were also characterized by X-ray crystallography. Preliminary in vitro tests of I and 3 were conducted using the MTT assay, which measures mitochondrial dehydrogenase activity as an indication of cell viability; these complexes showed in vitro anti-cancer activity against a human mammary cancer cell line (MDA-MB-435s) with IC50 values of 360 and 55 muM, respectively. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(03)00155-5